{"id":"W1970482109","doi":"10.1042/bj3590325","title":"Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"","keywords":"Matrix metalloproteinase; Proteolysis; Cell biology; Proteases; Transmembrane protein; Proteolytic enzymes; Metalloproteinase; Cytochalasin D; Biology; Chemistry; Biochemistry; Cytoskeleton; Cell; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006053393,0.0002437872,0.0002805606,0.0001068123,0.0001106265,0.00005299175,0.0003684797,0.0002738848,0.00005376043],"category_scores_gemma":[0.0002321964,0.0001738257,0.0001778225,0.0003395469,0.00009212562,0.00001805487,0.0001318571,0.0004219605,0.00001210026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004334392,"about_ca_system_score_gemma":0.0002057946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008158633,"about_ca_topic_score_gemma":0.000001949217,"domain_scores_codex":[0.9981857,0.0001069894,0.0005895993,0.0003277764,0.0003720101,0.0004179018],"domain_scores_gemma":[0.9990979,0.00001503439,0.0002834531,0.0002424674,0.0002048377,0.0001562624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006316092,0.0001138426,0.00002059649,0.00005506392,0.00002721605,0.00004169146,0.00002651302,0.00002986898,0.9980246,0.000009632366,0.0003904982,0.0006288445],"study_design_scores_gemma":[0.0008446974,0.0003475562,0.000007991086,0.0001735734,0.00002959542,0.0003472756,0.00005382672,0.00028886,0.9960316,0.00005884731,0.001593704,0.0002224164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99611,0.002605554,0.000241127,0.0002864501,0.0001871341,0.0004611702,0.000006513329,0.000009880815,0.00009216685],"genre_scores_gemma":[0.9979494,0.0002259335,0.0004589256,0.0001178419,0.00073338,0.00002639309,0.000004829825,0.00003382863,0.000449471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379621,"threshold_uncertainty_score":0.7088407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012486445792565,"score_gpt":0.2515182605995726,"score_spread":0.241393396141647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}