{"id":"W1970515032","doi":"10.1128/jb.01184-12","title":"The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages","year":2012,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":302,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"CRISPR; Biology; Bacteriophage; Lytic cycle; Trans-activating crRNA; Pseudomonas aeruginosa; Cas9; Computational biology; Microbiology; Genetics; Gene; Bacteria; Virus; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660161,0.0002214941,0.0002253396,0.0001748358,0.0002422151,0.0002938591,0.0002375616,0.0002174065,0.0008380884],"category_scores_gemma":[0.0001629968,0.0001029197,0.0001917632,0.00007094779,0.0002272515,0.0001463717,0.0002995038,0.0004824585,0.0003314401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069287,"about_ca_system_score_gemma":0.0002750223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003543838,"about_ca_topic_score_gemma":0.0006026527,"domain_scores_codex":[0.9998247,0.00003355207,0.00001394208,0.00003115246,0.00006449223,0.00003220222],"domain_scores_gemma":[0.9998965,0.00002204119,0.00002176401,0.00001722519,0.00001303112,0.00002934197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001976606,0.000009230669,0.000172204,0.00001519628,0.000001779515,0.00005949237,0.00001238619,0.00004016294,0.9983692,0.0001067811,0.000018559,0.001175267],"study_design_scores_gemma":[0.000008197268,0.000156166,0.002696214,0.000004519274,0.000005517858,0.0008205003,0.00003031487,0.0009364601,0.9921199,0.0001008887,0.003115063,0.000006277779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679985,0.001208723,0.0271138,0.0002691206,0.00004700769,0.00008484471,0.0002791077,0.000359778,0.002639151],"genre_scores_gemma":[0.9820306,0.0006210199,0.01384145,0.00007501528,0.00001605493,0.00005176817,0.0002751862,0.00003123779,0.003057712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008380884,"threshold_uncertainty_score":0.002803743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005809962767705519,"score_gpt":0.2588259902679446,"score_spread":0.253016027500239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}