{"id":"W1970553244","doi":"10.1002/hast.433","title":"The Structure of Clinical Translation: <i>Efficiency, Information, and Ethics</i>","year":2015,"lang":"en","type":"article","venue":"The Hastings Center Report","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Inefficiency; Set (abstract data type); Principal (computer security); Clinical trial; Translational research; Drug development; Computer science; Knowledge translation; Engineering ethics; Risk analysis (engineering); Medicine; Management science; Business; Knowledge management; Economics; Drug; Engineering; Computer security","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009513802,0.00005885684,0.00007781702,0.000006152835,0.000100205,0.00003136035,0.000116953,0.00007556464,0.000001056931],"category_scores_gemma":[0.00105066,0.00003404927,0.00003885298,0.00003434319,0.0001824707,0.000004136541,0.000069275,0.0001289031,6.046478e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000268612,"about_ca_system_score_gemma":0.0001879204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002216108,"about_ca_topic_score_gemma":0.00004085227,"domain_scores_codex":[0.9992282,0.00003467076,0.0004242733,0.00009046106,0.0001340212,0.00008839885],"domain_scores_gemma":[0.9991581,0.00008962236,0.0002619828,0.0002419971,0.0002001546,0.00004808265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002351888,0.0004149106,0.5718139,0.0002673545,0.0007120481,0.000049264,0.01998785,0.002962386,0.0675973,0.00588915,0.1213643,0.2065897],"study_design_scores_gemma":[0.001078899,0.0002199094,0.005643324,0.00001709928,0.0000332424,0.0004613532,0.0004462064,0.0002680359,0.01407075,0.00072013,0.9768996,0.0001414923],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896858,0.0007127667,0.004124691,0.002313297,0.000613123,0.0001746203,0.0000352132,0.000005470821,0.002334972],"genre_scores_gemma":[0.9987922,0.000165409,0.0002672948,0.0005131557,0.0001669292,0.000001000601,0.0000451503,0.000004281856,0.00004454823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8555353,"threshold_uncertainty_score":0.1388489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410876381886551,"score_gpt":0.3259959849644701,"score_spread":0.2818872211456046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}