{"id":"W1970553244","doi":"10.1002/hast.433","title":"The Structure of Clinical Translation: <i>Efficiency, Information, and Ethics</i>","year":2015,"lang":"en","type":"article","venue":"The Hastings Center Report","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Inefficiency; Set (abstract data type); Principal (computer security); Clinical trial; Translational research; Drug development; Computer science; Knowledge translation; Engineering ethics; Risk analysis (engineering); Medicine; Management science; Business; Knowledge management; Economics; Drug; Engineering; Computer security","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.1098741,0.0008562731,0.001567473,0.005288215,0.007265002,0.02876126,0.003399333,0.01409252,0.01117858],"category_scores_gemma":[0.1708113,0.001133815,0.001613825,0.004320844,0.1101975,0.03017242,0.009941374,0.009449018,0.00211292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0191251,"about_ca_system_score_gemma":0.01735515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003516055,"about_ca_topic_score_gemma":0.001289832,"domain_scores_codex":[0.8486581,0.1241055,0.005508448,0.007234257,0.01044129,0.004052284],"domain_scores_gemma":[0.6350139,0.2944284,0.01438437,0.03573793,0.01692077,0.003514642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00002082716,0.00001264664,0.00017663,0.00004682837,0.000008523705,0.00003523434,0.001055083,0.00055545,0.0000370034,0.9926036,0.001305798,0.004142296],"study_design_scores_gemma":[0.00002772745,0.00001968377,0.0001709602,0.0001351641,0.000009965512,0.00003837874,0.0003872698,0.001787385,0.0001637773,0.9877844,0.009458604,0.00001675364],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02707454,0.006640251,0.2552803,0.4189216,0.0009289763,0.0006032513,0.0002517464,0.000368869,0.2899305],"genre_scores_gemma":[0.9267204,0.001484154,0.04590935,0.01462908,0.001193312,0.0006922879,0.0001048382,0.0001566434,0.009109974],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.992735,"threshold_uncertainty_score":0.5810769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410876381886551,"score_gpt":0.3259959849644701,"score_spread":0.2818872211456046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}