{"id":"W1970554609","doi":"10.1016/j.reprotox.2014.04.001","title":"Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: Highlights from animal studies","year":2014,"lang":"en","type":"review","venue":"Reproductive Toxicology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Genomics; St. Michael's Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Biology; Mevalonate pathway; Morphogenesis; HMG-CoA reductase; Reductase; Coenzyme A; Cell biology; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009782239,0.0007944474,0.001790882,0.0001245189,0.0004207252,0.00005418676,0.0008939698,0.0006889661,0.00004222204],"category_scores_gemma":[0.002727702,0.0005165279,0.0003162621,0.0004577316,0.0007708241,0.00001238408,0.0007477704,0.0006087794,0.00008617991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002252487,"about_ca_system_score_gemma":0.001200948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006197509,"about_ca_topic_score_gemma":0.00005890069,"domain_scores_codex":[0.9946715,0.001042055,0.0008480681,0.002266143,0.0003522059,0.0008200129],"domain_scores_gemma":[0.9975142,0.0002796379,0.0005714608,0.001032618,0.0004264076,0.0001756019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000430275,0.0004379464,0.00000824325,0.004791879,0.004992994,0.0000895153,0.0003641309,0.000002592162,0.5383891,0.0001007361,0.08574791,0.3646446],"study_design_scores_gemma":[0.00027592,0.000621542,0.000004783097,0.0005802448,0.0002494549,0.0001941454,0.0001442701,7.901941e-7,0.07786706,0.00008891957,0.9193988,0.0005741074],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05891165,0.9382252,0.00001353394,0.0007222986,0.0003126246,0.001334911,0.0002792253,0.00004528716,0.0001552536],"genre_scores_gemma":[0.002295519,0.9894719,0.0003913658,0.0001348567,0.001707764,0.0004897042,0.001331549,0.0001033682,0.004073999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8336508,"threshold_uncertainty_score":0.9997286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04357062893467475,"score_gpt":0.3418679913335817,"score_spread":0.298297362398907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}