{"id":"W1970565116","doi":"10.1038/ng.2859","title":"Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections","year":2013,"lang":"en","type":"letter","venue":"Nature Genetics","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Biology; Cystic fibrosis; Adaptation (eye); Genome; Pathogen; Population; Chronic infection; Genetics; Burkholderia; Computational biology; Evolutionary biology; Gene; Bacteria; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006007728,0.0002135764,0.0003975967,0.0002634352,0.0006775628,0.000691909,0.0004331343,0.005809738,0.001267484],"category_scores_gemma":[0.003828635,0.000173663,0.0002830307,0.0002337963,0.0009036711,0.0006343319,0.0003836928,0.00393995,0.0004981312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009740192,"about_ca_system_score_gemma":0.0002970687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008606103,"about_ca_topic_score_gemma":0.001393175,"domain_scores_codex":[0.999464,0.0001941027,0.00005764275,0.00006315092,0.0000879596,0.0001331346],"domain_scores_gemma":[0.9983341,0.0009372752,0.0001572314,0.0001216319,0.0001782447,0.000271564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.004497473,0.0005455379,0.1890914,0.0002897435,0.0001763726,0.3394325,0.001938953,0.001016715,0.07543711,0.01013946,0.2833094,0.0941254],"study_design_scores_gemma":[0.0009600816,0.001726415,0.3559404,0.0004713504,0.0002774501,0.3672038,0.00371567,0.008111791,0.01505671,0.03041753,0.2158553,0.000263523],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4336568,0.003836016,0.00173824,0.5317296,0.009846251,0.0000678977,0.0002744911,0.0001561036,0.01869462],"genre_scores_gemma":[0.8507337,0.001310811,0.0008318664,0.1267772,0.01634021,0.00003860042,0.00007733336,0.00003437156,0.003855938],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005809738,"threshold_uncertainty_score":0.007067025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009058756557766506,"score_gpt":0.2294196995049967,"score_spread":0.2203609429472302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}