{"id":"W1970566968","doi":"10.1039/c3bm60200a","title":"Pharmacokinetics and transgene expression of implanted polyethylenimine-based pDNA complexes","year":2013,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Polyethylenimine; Transfection; Gene delivery; Reporter gene; Molecular biology; Genetic enhancement; Chemistry; Gene expression; Transgene; Naked DNA; In vivo; Messenger RNA; Gene; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477569,0.0001052082,0.0001211063,0.00006530909,0.00006840569,0.00004634056,0.0002474939,0.00004881065,0.00008823318],"category_scores_gemma":[0.0000189567,0.00008388989,0.00002549302,0.00009143475,0.0004218575,0.00001082964,0.00007383964,0.000008634885,0.000006820173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003117719,"about_ca_system_score_gemma":0.00005665192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007094582,"about_ca_topic_score_gemma":0.000001998161,"domain_scores_codex":[0.9991828,0.00002794813,0.0001972352,0.000264424,0.0001339857,0.0001936736],"domain_scores_gemma":[0.9995363,0.000006621229,0.00007654025,0.0001880924,0.0001130568,0.00007933057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004262639,0.0000236024,0.0003465597,0.00002021217,0.000002530001,3.729404e-7,0.00002141554,0.000003097179,0.9986939,0.000002595903,0.0003041025,0.0005389988],"study_design_scores_gemma":[0.0003017824,0.0002008755,0.006429349,0.00002363505,0.000005235824,0.000007240301,0.00002417793,0.00008571056,0.9925971,0.00001217115,0.0002049504,0.0001077586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988484,0.0002182258,0.0004385473,0.00005962662,0.000170614,0.0001443267,0.0000535717,0.000008665686,0.0000580465],"genre_scores_gemma":[0.9984933,0.00006665836,0.001225431,0.0001022952,0.00005020307,0.00001173871,0.00002357827,0.000006201344,0.00002066854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006096773,"threshold_uncertainty_score":0.3420931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135333980569983,"score_gpt":0.265328756657389,"score_spread":0.2517953586003907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}