{"id":"W1970573724","doi":"10.1074/jbc.m114.572164","title":"A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Linker; Steric effects; HCN channel; Tetramer; Biophysics; Hyperpolarization (physics); Stereochemistry; Transmembrane domain; Dimer; Ion channel; Allosteric regulation; Transmembrane protein; Crystallography; Biochemistry; Membrane; Nuclear magnetic resonance spectroscopy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096653,0.000483876,0.0003438832,0.0001993186,0.0004035421,0.0003805707,0.0009408636,0.0008949639,0.00148964],"category_scores_gemma":[0.0001921731,0.0002658508,0.0005093844,0.00007522676,0.0007771827,0.0007108929,0.0004962395,0.0007066524,0.0003182628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005353153,"about_ca_system_score_gemma":0.0003691706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004243801,"about_ca_topic_score_gemma":0.0003923325,"domain_scores_codex":[0.9998388,0.00001823285,0.00001072367,0.00005259216,0.00002858538,0.00005101166],"domain_scores_gemma":[0.9999037,0.00001851097,0.00002877259,0.00001651554,0.00001060364,0.00002194959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333335,0.00006547035,0.0002385918,0.0001342048,0.00001500415,0.0003694294,0.00004151346,0.0003346928,0.9938041,0.002489676,0.000166444,0.00220759],"study_design_scores_gemma":[0.0001304014,0.0006096561,0.005646242,0.00003093071,0.00002625651,0.001486776,0.0001112164,0.009384096,0.9761994,0.001692059,0.004642542,0.00004015356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582159,0.004809129,0.02759192,0.00144082,0.0003427826,0.0003096547,0.0002645234,0.000612911,0.006412284],"genre_scores_gemma":[0.9888981,0.0009947761,0.006521375,0.0003433133,0.00005588515,0.0001661701,0.0001316592,0.0000151954,0.002873538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148964,"threshold_uncertainty_score":0.004983366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624177096190442,"score_gpt":0.2346754555496397,"score_spread":0.2184336845877353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}