{"id":"W1970575961","doi":"10.1371/journal.pntd.0000491","title":"First-Line Therapy for Human Cutaneous Leishmaniasis in Peru Using the TLR7 Agonist Imiquimod in Combination with Pentavalent Antimony","year":2009,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Drugs for Neglected Diseases initiative; Universidad Peruana Cayetano Heredia","keywords":"Medicine; Imiquimod; Placebo; Rash; Cutaneous leishmaniasis; Adverse effect; Dermatology; Clinical trial; Randomized controlled trial; Internal medicine; Leishmania braziliensis; Erythema; Surgery; Gastroenterology; Leishmaniasis; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000859032,0.0005108531,0.001016175,0.0004033041,0.0003218116,0.0002421204,0.0003790467,0.0004350374,0.002268676],"category_scores_gemma":[0.0005479797,0.0002550932,0.0003967126,0.000226235,0.0004310378,0.0002150218,0.0003117215,0.0005826381,0.0003071709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805783,"about_ca_system_score_gemma":0.0004355795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005156971,"about_ca_topic_score_gemma":0.00145407,"domain_scores_codex":[0.9997914,0.0001150581,0.00001263863,0.00002530241,0.00002611073,0.00002949417],"domain_scores_gemma":[0.999696,0.00007550434,0.00009322483,0.00002253471,0.00002994149,0.00008283155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2336918,0.07692453,0.0438463,0.008410999,0.001879177,0.0009674651,0.0006824823,0.0009663139,0.2737324,0.0002790538,0.002791294,0.3558283],"study_design_scores_gemma":[0.1262504,0.7323248,0.1094661,0.0004258988,0.001530091,0.001517115,0.0002026268,0.0007562924,0.02103292,0.0001508407,0.006309314,0.00003354835],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894018,0.007336232,0.0004540279,0.0002910804,0.00003302032,0.001373294,0.0001422542,0.00004373188,0.0009245842],"genre_scores_gemma":[0.9927626,0.00421784,0.0009351402,0.0002706306,0.00009894929,0.0009220507,0.0002575192,0.000004593618,0.0005306316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268676,"threshold_uncertainty_score":0.007589459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04476231338081516,"score_gpt":0.3191270143308811,"score_spread":0.2743647009500659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}