{"id":"W1970577477","doi":"10.1128/jvi.02457-08","title":"ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication","year":2009,"lang":"en","type":"article","venue":"Journal of Virology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Foundation for AIDS Research","keywords":"Protein kinase R; Biology; Interferon; EIF-2 kinase; RNA; Molecular biology; Antiviral protein; RNA-binding protein; Viral replication; Virology; Virus; RNA silencing; Protein kinase A; RNA interference; Cell biology; Kinase; Gene; Genetics; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706683,0.0003229472,0.0002101815,0.0002013208,0.0002202524,0.0004028438,0.0002134351,0.0002397008,0.001327931],"category_scores_gemma":[0.0001477061,0.0002033482,0.0002650248,0.0001159174,0.0001377729,0.0002285989,0.0002205839,0.0004889824,0.0008346103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000415017,"about_ca_system_score_gemma":0.0001185387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001913463,"about_ca_topic_score_gemma":0.0002413248,"domain_scores_codex":[0.9997875,0.00003756045,0.00001557009,0.00005979467,0.00005126458,0.00004823138],"domain_scores_gemma":[0.9999241,0.000009131797,0.00002501458,0.000007538207,0.000008495681,0.00002574532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153809,0.0000176129,0.0005087758,0.00003252988,0.000005564919,0.00007661531,0.00001290636,0.00002576444,0.9976944,0.0000659286,0.00004856275,0.001395788],"study_design_scores_gemma":[0.00002592953,0.0001980591,0.03202852,0.00001373586,0.00003056306,0.001310306,0.00004498893,0.001558646,0.9597548,0.000108586,0.004916245,0.000009621881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905112,0.00493536,0.002233234,0.0001242396,0.0000343942,0.00001604992,0.0001706663,0.00007633054,0.001898507],"genre_scores_gemma":[0.9939434,0.001163112,0.001475897,0.00005747402,0.00002422066,0.00002232284,0.0005303847,0.0000197421,0.002763555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327931,"threshold_uncertainty_score":0.004442394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004582070862319132,"score_gpt":0.2610987378684439,"score_spread":0.2565166670061247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}