{"id":"W1970604092","doi":"10.1016/j.ejmech.2005.02.005","title":"Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates","year":2005,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Pyrrole; Imidazole; Polyamide; Stereochemistry; Combinatorial chemistry; In vitro; Conjugate; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118334,0.0003091216,0.0001910114,0.000122398,0.000123933,0.0002075638,0.0002662011,0.0001729935,0.0009140535],"category_scores_gemma":[0.0001993652,0.0001441099,0.0001574125,0.0001310893,0.0001553425,0.0002497225,0.000133204,0.0002112922,0.0002401696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511537,"about_ca_system_score_gemma":0.0001741321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003446527,"about_ca_topic_score_gemma":0.0005642559,"domain_scores_codex":[0.9999152,0.00001971766,0.00001032437,0.0000177264,0.00001871928,0.00001823893],"domain_scores_gemma":[0.9998932,0.00002162907,0.00003834881,0.00001125934,0.00001767112,0.00001789532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001870488,0.00006594545,0.00006241738,0.00005569739,0.000003590845,0.00005968577,0.00002562034,0.0004183476,0.9959444,0.0001347069,0.00002754114,0.00301506],"study_design_scores_gemma":[0.00003714735,0.001476521,0.0005396892,0.000002953044,0.00001665693,0.0001177928,0.000007029754,0.0005264925,0.9957381,0.00001651513,0.001516984,0.000004011175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879822,0.001740548,0.007572676,0.00004479388,0.00002923682,0.000172277,0.0001680725,0.00006303331,0.002227143],"genre_scores_gemma":[0.9900732,0.001373191,0.005435295,0.00002594333,0.00001187113,0.0001293341,0.0003065683,0.00001469629,0.002629816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009140535,"threshold_uncertainty_score":0.003057837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219036408863442,"score_gpt":0.2874554423725375,"score_spread":0.245265078283903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}