{"id":"W1970635130","doi":"10.1007/s00018-008-8588-y","title":"Medium- and short-chain dehydrogenase/reductase gene and protein families","year":2008,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":908,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Novo Nordisk; Ontario Genomics Institute; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Biochemistry; Cofactor; NAD+ kinase; Biology; Active site; Dehydrogenase; Binding site; Sequence motif; Consensus sequence; Oxidoreductase; Conserved sequence; Walker motifs; Peptide sequence; Nucleotide; Enzyme; Chemistry; Stereochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002520785,0.0008414536,0.0009629861,0.001392237,0.0002411403,0.0007170458,0.0008887889,0.0006420795,0.003753555],"category_scores_gemma":[0.0002937613,0.0001552812,0.0002245795,0.001931625,0.0004295525,0.001096296,0.0003824811,0.0007336232,0.004402557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006592771,"about_ca_system_score_gemma":0.0007394028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000818736,"about_ca_topic_score_gemma":0.001091669,"domain_scores_codex":[0.9998873,0.00001051095,0.00001178009,0.00003164248,0.00004596825,0.00001263054],"domain_scores_gemma":[0.9998952,0.00002054818,0.00001753068,0.000006014884,0.00004361275,0.00001701894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005166946,0.00002802089,0.0001566637,0.002780432,0.00002227982,0.0002249764,0.00002929923,0.0002057473,0.004532088,0.004044673,0.01475718,0.9731669],"study_design_scores_gemma":[0.000006036865,0.00002682612,0.0005029705,0.0002932931,0.00001676866,0.0009449084,0.00002312693,0.00005065236,0.0009683334,0.001036254,0.9961235,0.000007206774],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006410322,0.9919904,0.0009922868,0.0003390903,0.000439155,0.00001415699,0.00006192124,0.00003746005,0.005484517],"genre_scores_gemma":[0.004447575,0.9832898,0.001951687,0.0002098497,0.0002617406,0.00002617562,0.0002113772,0.000005957754,0.009595811],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003753555,"threshold_uncertainty_score":0.01255685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02463567778086382,"score_gpt":0.2615088243901261,"score_spread":0.2368731466092623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}