{"id":"W1970659783","doi":"10.4161/19336950.2014.951250","title":"Some assembly required: SOCE and Orai1 channels couple to NFAT transcriptional activity via calmodulin and calcineurin","year":2014,"lang":"en","type":"letter","venue":"Channels","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bible College; University of Calgary","funders":"","keywords":"Second messenger system; Calmodulin; Signal transduction; Cell biology; NFAT; Crosstalk; ORAI1; Intracellular; Cell signaling; Biology; Calcium signaling; Chemistry; Transcription factor; STIM1; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003742213,0.000312719,0.0002704418,0.0001778786,0.0008776108,0.0007864895,0.0004185776,0.003776741,0.002359735],"category_scores_gemma":[0.001852437,0.0001471389,0.0003218729,0.00009375958,0.00102584,0.0006728493,0.0003259795,0.00364332,0.001410074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001795366,"about_ca_system_score_gemma":0.0004118355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009100084,"about_ca_topic_score_gemma":0.001692701,"domain_scores_codex":[0.9996618,0.0000682203,0.00003044031,0.00005643086,0.0001162201,0.00006693532],"domain_scores_gemma":[0.999556,0.000148673,0.00006160046,0.00004847357,0.0001099367,0.00007523558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001346738,0.0002904871,0.00556697,0.0006544405,0.00008417408,0.06771233,0.0006938716,0.0006297452,0.1793672,0.05965433,0.5586675,0.1253321],"study_design_scores_gemma":[0.0002900166,0.0002796045,0.005721062,0.0001016577,0.0000405833,0.04156574,0.0002704237,0.004572657,0.05995671,0.02400844,0.8631498,0.00004330109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07769506,0.02316164,0.008409658,0.7789057,0.03834105,0.0001481609,0.0001821729,0.0008106593,0.07234583],"genre_scores_gemma":[0.661126,0.01188598,0.006441704,0.1887511,0.0407189,0.0002526714,0.0002902434,0.0001144926,0.090419],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003776741,"threshold_uncertainty_score":0.01302636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05718997413006171,"score_gpt":0.2821353279949546,"score_spread":0.2249453538648929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}