{"id":"W1970659783","doi":"10.4161/19336950.2014.951250","title":"Some assembly required: SOCE and Orai1 channels couple to NFAT transcriptional activity via calmodulin and calcineurin","year":2014,"lang":"en","type":"letter","venue":"Channels","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bible College; University of Calgary","funders":"","keywords":"Second messenger system; Calmodulin; Signal transduction; Cell biology; NFAT; Crosstalk; ORAI1; Intracellular; Cell signaling; Biology; Calcium signaling; Chemistry; Transcription factor; STIM1; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004359174,0.0009205203,0.001056529,0.0004498258,0.0005244625,0.0003127649,0.0005459233,0.001199575,0.0001058259],"category_scores_gemma":[0.000186087,0.0008284481,0.0002218153,0.0003488272,0.000383624,0.000513039,0.0002580854,0.001609163,0.0001701382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057457,"about_ca_system_score_gemma":0.00007523644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000109055,"about_ca_topic_score_gemma":0.000004132779,"domain_scores_codex":[0.9951209,0.0003341233,0.0005152713,0.001949399,0.0008897182,0.001190553],"domain_scores_gemma":[0.9982697,0.000432224,0.000265797,0.0004416388,0.0001061427,0.000484475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001282791,0.0001330567,0.000004472608,0.0006947111,0.00004022708,0.0003432875,0.001098213,0.0002525312,0.5112173,0.0001882739,0.4836691,0.002230578],"study_design_scores_gemma":[0.001483805,0.000783563,0.00004635295,0.0003750467,0.00009539865,0.0005455357,0.00002925684,0.009080526,0.345038,0.001964978,0.6383742,0.002183306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4220548,0.0005837522,0.003534871,0.5597578,0.01129392,0.001823658,0.0004447819,0.0003512385,0.0001551143],"genre_scores_gemma":[0.6595127,0.0004358674,0.00004718246,0.3153816,0.01644681,0.0002037278,0.00007359005,0.0002170843,0.007681427],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2443762,"threshold_uncertainty_score":0.9994166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05718997413006171,"score_gpt":0.2821353279949546,"score_spread":0.2249453538648929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}