{"id":"W1970708036","doi":"10.1103/physrevlett.107.218101","title":"Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation","year":2011,"lang":"en","type":"article","venue":"Physical Review Letters","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Biology; Gene; Mutation; Adaptation (eye); Population; Genetics; Drug resistance; Gene expression; Computational biology; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166252,0.00009942891,0.0001783127,0.00001751427,0.00002538616,0.000002299639,0.00007873061,0.00001143493,0.000005548636],"category_scores_gemma":[0.00002986059,0.00008746619,0.00009109959,0.00007548586,0.00005848576,0.000006245542,0.00003690406,0.00003593186,0.00000344769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005309329,"about_ca_system_score_gemma":0.000008597684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005853448,"about_ca_topic_score_gemma":0.000005618779,"domain_scores_codex":[0.9992791,0.00009472878,0.0001738163,0.0002278335,0.0001279611,0.00009659097],"domain_scores_gemma":[0.9995611,0.00001095691,0.0001262547,0.0002116108,0.00004610987,0.00004396815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002527923,0.00003567474,0.0004433859,0.0002617151,0.00003491139,0.00000124113,0.0002665731,0.00009144754,0.9959297,0.000007345745,0.001102844,0.001799866],"study_design_scores_gemma":[0.0002507532,0.00003793734,0.005339206,0.0004030433,0.0001589473,0.000001832158,0.0000464111,0.0002613126,0.9918121,0.0001642617,0.001304966,0.0002192766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783402,0.01881788,0.002457612,0.0001798778,0.00001470014,0.000139004,0.000004538943,0.000004667971,0.00004149345],"genre_scores_gemma":[0.9937555,0.003793887,0.001832655,0.0004692836,0.00004157942,0.00001917678,0.00004692896,0.000008875003,0.00003208948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154153,"threshold_uncertainty_score":0.3566768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595894481935107,"score_gpt":0.2428534461346588,"score_spread":0.2268945013153077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}