{"id":"W1970708036","doi":"10.1103/physrevlett.107.218101","title":"Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation","year":2011,"lang":"en","type":"article","venue":"Physical Review Letters","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Biology; Gene; Mutation; Adaptation (eye); Population; Genetics; Drug resistance; Gene expression; Computational biology; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002587122,0.0002235905,0.0002813624,0.0001555946,0.0001581761,0.0004981395,0.0002758603,0.0003107998,0.0007598946],"category_scores_gemma":[0.001101178,0.0001341335,0.0003125306,0.0001215699,0.0005506127,0.0004031498,0.0002483911,0.0004430673,0.0001445435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003950915,"about_ca_system_score_gemma":0.0001609328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003975785,"about_ca_topic_score_gemma":0.0004900642,"domain_scores_codex":[0.9998598,0.00003385888,0.000007453458,0.00004487575,0.0000329909,0.00002087856],"domain_scores_gemma":[0.9994624,0.000349359,0.00008218114,0.00005154028,0.00001954702,0.00003497465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002047149,0.00004273416,0.003944044,0.00008350267,0.00003936982,0.0004435082,0.00007193122,0.08786239,0.8641583,0.03417678,0.0002311143,0.008741517],"study_design_scores_gemma":[0.00002802548,0.0002035607,0.009312251,0.000008553224,0.00004481945,0.0005084815,0.00005216729,0.7468574,0.2079973,0.03324139,0.001710317,0.00003574644],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351957,0.0002112983,0.06245475,0.000340996,0.00002689431,0.00000611832,0.00003992759,0.00009329186,0.001630976],"genre_scores_gemma":[0.9960291,0.0001489671,0.003233642,0.00003148133,0.000008926144,0.000007325184,0.00002158608,0.00001127082,0.0005076684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007598946,"threshold_uncertainty_score":0.002866566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01595894481935107,"score_gpt":0.2428534461346588,"score_spread":0.2268945013153077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}