{"id":"W1970749133","doi":"10.1038/cdd.2008.30","title":"The SCFFSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans","year":2008,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; Discovery Centre","funders":"Natural Sciences and Engineering Research Council of Canada; University of Dundee; Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Innovation Trust","keywords":"Cullin; Ubiquitin ligase; Skp1; Biology; Caenorhabditis elegans; Neddylation; Molecular biology; Cell biology; F-box protein; Germline; Inhibitor of apoptosis; Apoptosis; Ubiquitin; Genetics; Programmed cell death; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001034261,0.0001662135,0.0001493905,0.00002651774,0.0002511257,0.00004698475,0.0001234758,0.0001342082,0.00001009825],"category_scores_gemma":[0.00003772083,0.0001324884,0.00006242884,0.00004696664,0.0000726988,0.000007350993,0.00005966803,0.00009713339,0.000006709942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001159064,"about_ca_system_score_gemma":0.00003462824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007391227,"about_ca_topic_score_gemma":0.00009817474,"domain_scores_codex":[0.9990002,0.00006640831,0.0002409153,0.0002935759,0.0001200662,0.0002788179],"domain_scores_gemma":[0.9995055,0.0000256612,0.00008867602,0.0002568002,0.00005377316,0.00006959047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402962,0.0002744732,0.06357585,0.00004934043,0.00004122339,0.000004066269,0.00141717,0.0001387335,0.9314421,0.0004458562,0.001158784,0.001312085],"study_design_scores_gemma":[0.002022012,0.000246387,0.08679973,0.00001219979,0.00004880365,0.00001135215,0.0001502238,0.001126807,0.9030614,0.0007676125,0.005418262,0.0003351841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896577,0.001843418,0.007335383,0.0002048602,0.0001562345,0.0002209041,0.0000111439,0.00001241589,0.0005579551],"genre_scores_gemma":[0.9942976,0.003931365,0.0002621152,0.000301386,0.0001939204,0.00002366991,0.0001523351,0.00001880477,0.0008188494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02838069,"threshold_uncertainty_score":0.5402719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187310607392813,"score_gpt":0.2189785807041237,"score_spread":0.2071054746301956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}