{"id":"W1970754475","doi":"10.1016/j.neuint.2006.02.002","title":"Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma","year":2006,"lang":"en","type":"article","venue":"Neurochemistry International","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Hôpital Saint-Luc","funders":"Canadian Institutes of Health Research","keywords":"Allopregnanolone; Neuroactive steroid; Endocrinology; Internal medicine; Coma (optics); Pregnenolone; GABAA receptor; Hepatic encephalopathy; Pregnanolone; Muscimol; Agonist; Benzodiazepine; Medicine; Cirrhosis; Receptor; Hormone; Steroid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003792423,0.00014324,0.0002586461,0.0001221561,0.00001216668,0.00001052861,0.00008907721,0.00007420377,0.00007606857],"category_scores_gemma":[0.00007641636,0.0001569414,0.00003244351,0.000123863,0.00004535605,0.0001226045,0.00002946839,0.000146952,0.000002281154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004465161,"about_ca_system_score_gemma":0.00004672257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003874589,"about_ca_topic_score_gemma":0.000037377,"domain_scores_codex":[0.9988463,0.00004866439,0.0003599062,0.0003086419,0.0002979786,0.000138505],"domain_scores_gemma":[0.9994381,0.0001584804,0.0001242988,0.0001186919,0.0001020106,0.00005844016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005030659,0.0006390843,0.4086827,0.000159217,0.00009306161,0.0002234731,0.000332816,0.00001953277,0.5890213,0.00006814038,0.000010337,0.0002472092],"study_design_scores_gemma":[0.003043968,0.00004147433,0.7389929,0.000207121,0.00007238624,0.000008484828,0.000008527321,0.0006901217,0.2566435,0.0002044054,0.000007263762,0.00007986374],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997967,0.0001754996,0.00001530889,0.0002637574,0.00006714044,0.0002651208,0.0003836583,0.00001712795,0.0008453826],"genre_scores_gemma":[0.9988558,0.00002929209,0.00004063556,0.0001535023,0.00004229707,0.00002243898,0.0007252196,0.00001464929,0.0001162131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3323778,"threshold_uncertainty_score":0.6399884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008609049480576957,"score_gpt":0.2489156855302365,"score_spread":0.2403066360496595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}