{"id":"W1970777708","doi":"10.1074/jbc.m606062200","title":"Paradoxical Striatal Cellular Signaling Responses to Psychostimulants in Hyperactive Mice","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Dopamine transporter; Dopamine; MAPK/ERK pathway; Amphetamine; Monoaminergic; Pharmacology; Protein kinase B; Methylphenidate; Protein kinase A; Endocrinology; Signal transduction; Internal medicine; Biology; Dopaminergic; Chemistry; Serotonin; Kinase; Medicine; Cell biology; Receptor; Attention deficit hyperactivity disorder","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190743,0.001053924,0.0005202405,0.001753522,0.000298071,0.0006112678,0.0004954802,0.0008211249,0.002416203],"category_scores_gemma":[0.0001745848,0.0004735926,0.0005218959,0.0003486119,0.0009123355,0.0003001702,0.0004890248,0.001699455,0.0004567526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000776094,"about_ca_system_score_gemma":0.000415595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147023,"about_ca_topic_score_gemma":0.003416847,"domain_scores_codex":[0.9995632,0.00005279028,0.00004803801,0.0001299864,0.0001167184,0.00008927732],"domain_scores_gemma":[0.9995196,0.00004991688,0.0001688784,0.00003582871,0.00002307461,0.0002027561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894545,0.00006859207,0.0002099366,0.00002309092,0.000013151,0.0001862534,0.00002353321,0.00006572128,0.9979081,0.0001865186,0.00004594718,0.001079643],"study_design_scores_gemma":[0.0001133554,0.0007801735,0.01414604,0.0000294433,0.00007260648,0.001237581,0.000110435,0.00156919,0.979494,0.0004155366,0.002006439,0.00002516801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931344,0.0009996853,0.002034768,0.0003158077,0.0000445566,0.00004702167,0.00162609,0.0004288258,0.001368882],"genre_scores_gemma":[0.9865585,0.001493806,0.004383792,0.0002998351,0.00002620179,0.0001844632,0.001796044,0.0001946041,0.005062801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002416203,"threshold_uncertainty_score":0.008082986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05925367840377457,"score_gpt":0.3186490333640767,"score_spread":0.2593953549603021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}