{"id":"W1970785285","doi":"10.4161/cc.6.8.4105","title":"BRCA1 Haploinsufficiency, but not Heterozygosity for a BRCA1-truncating Mutation, Deregulates Homologous Recombination","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Haploinsufficiency; Biology; Loss of heterozygosity; Homologous recombination; Genetics; Allele; DNA repair; Genome instability; Wild type; Mutation; Homologous chromosome; Cancer research; Phenotype; Mutant; Molecular biology; DNA damage; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018955,0.0001277691,0.0001014861,0.00004600085,0.0001387787,0.00002475815,0.0001285721,0.000122557,0.00000670958],"category_scores_gemma":[0.00008281729,0.0001407101,0.00007832354,0.00007019078,0.00003438569,0.000004154372,0.00004514266,0.00005413898,0.000007159105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000214925,"about_ca_system_score_gemma":0.00002165396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000312734,"about_ca_topic_score_gemma":0.00005445707,"domain_scores_codex":[0.9990987,0.00001236995,0.0002159114,0.000301426,0.00008430934,0.0002873091],"domain_scores_gemma":[0.999529,0.00003565197,0.00006886626,0.0001988535,0.0001008063,0.00006680222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003235921,0.00009142686,0.0005972085,0.00004449491,0.0000112506,0.000002459278,0.0001385636,0.002757732,0.9870731,0.00002953634,0.0001868894,0.009034987],"study_design_scores_gemma":[0.000568852,0.0002153886,0.01799682,0.000006043383,0.00001369773,0.00002084577,0.0001161595,0.002747529,0.9770925,0.0001675466,0.0008661071,0.0001885007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8249153,0.0003487229,0.1737426,0.00003770755,0.000189522,0.000201293,0.000008053491,0.00002884683,0.0005278938],"genre_scores_gemma":[0.994033,0.00001710129,0.005204096,0.00008697823,0.000131167,0.00001725508,0.0001081845,0.00002496019,0.0003772229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1691177,"threshold_uncertainty_score":0.5737991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006980131369100921,"score_gpt":0.2717742563932637,"score_spread":0.2647941250241628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}