{"id":"W1970785285","doi":"10.4161/cc.6.8.4105","title":"BRCA1 Haploinsufficiency, but not Heterozygosity for a BRCA1-truncating Mutation, Deregulates Homologous Recombination","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Haploinsufficiency; Biology; Loss of heterozygosity; Homologous recombination; Genetics; Allele; DNA repair; Genome instability; Wild type; Mutation; Homologous chromosome; Cancer research; Phenotype; Mutant; Molecular biology; DNA damage; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412157,0.0002068338,0.0002059023,0.0002348495,0.000117099,0.0001967171,0.0001436925,0.0002035647,0.001271054],"category_scores_gemma":[0.0000924765,0.0001273628,0.000101083,0.0001347978,0.0002000444,0.00005703608,0.0001411365,0.0002077903,0.000297265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220577,"about_ca_system_score_gemma":0.0001265073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004650727,"about_ca_topic_score_gemma":0.0009634257,"domain_scores_codex":[0.9999083,0.00001609746,0.000009477812,0.00002289475,0.00002644694,0.00001667267],"domain_scores_gemma":[0.9999204,0.00001675648,0.00002707317,0.00001340856,0.000004951552,0.00001741257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002813111,0.0000123021,0.0005505627,0.0000219918,0.000003808439,0.0001057704,0.00001509173,0.0000336104,0.9978884,0.0001067001,0.00004067417,0.001193025],"study_design_scores_gemma":[0.00001476955,0.0002519747,0.02155354,0.00001219505,0.00002071323,0.002636123,0.00004047281,0.0007022075,0.9679801,0.00008413999,0.006697463,0.000006127754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963549,0.0009340266,0.001202652,0.00006762188,0.00001355621,0.00001704985,0.0003123296,0.00006878576,0.001029049],"genre_scores_gemma":[0.9959658,0.0005724793,0.00115625,0.00002592431,0.000004954622,0.00001821971,0.0005369943,0.00001368584,0.001705612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271054,"threshold_uncertainty_score":0.004252076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006980131369100921,"score_gpt":0.2717742563932637,"score_spread":0.2647941250241628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}