{"id":"W1970821362","doi":"10.1007/s11060-007-9436-x","title":"Down-regulation of the inhibitor of growth 1 (ING1) tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death","year":2007,"lang":"en","type":"article","venue":"Journal of Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Cisplatin; Cancer research; DNA damage; DNA repair; Biology; Gene knockdown; Tumor suppressor gene; Tumor progression; Apoptosis; Histone; Programmed cell death; Cell growth; Carcinogenesis; Cancer; DNA; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007748803,0.0001550079,0.0003367545,0.0001598231,0.00005505946,0.000008455524,0.000226669,0.0001727608,0.000008363572],"category_scores_gemma":[0.0002937459,0.0001180758,0.0002089658,0.0001906013,0.00005928747,0.000006490749,0.0001331358,0.0001848042,0.000001458199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004609212,"about_ca_system_score_gemma":0.0001885771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009208134,"about_ca_topic_score_gemma":0.00002149518,"domain_scores_codex":[0.9981965,0.0002062745,0.0008447713,0.0001965199,0.0003205818,0.000235375],"domain_scores_gemma":[0.997795,0.000184102,0.001050143,0.0002502712,0.0005985977,0.0001219112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006012197,0.000189914,0.001075846,0.00002714082,0.00001930796,0.00001537756,0.0001837059,0.001233848,0.9958012,0.00002203118,0.0002295014,0.0006009729],"study_design_scores_gemma":[0.0008483975,0.003513186,0.01468965,0.0000235125,0.00005248248,0.00005914874,0.00007733514,0.00006869871,0.9776247,0.00006128573,0.00287853,0.0001031046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968288,0.0001192201,0.001206625,0.0002327609,0.0008370846,0.0002163726,0.00001139275,0.000002264059,0.000545492],"genre_scores_gemma":[0.9977727,0.00002302865,0.00167428,0.0001850389,0.0002971371,0.000001078193,0.000001850032,0.00002075986,0.00002410806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01817647,"threshold_uncertainty_score":0.4814992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164920517668464,"score_gpt":0.2639897216965159,"score_spread":0.2523405165198312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}