{"id":"W1970837608","doi":"10.1016/j.chom.2014.07.002","title":"Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens","year":2014,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":440,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Inflammasome; Biology; Salmonella enterica; Innate immune system; Intestinal epithelium; Caspase 1; Microbiology; Proinflammatory cytokine; Caspase; Cell biology; Intracellular; Pyroptosis; Epithelium; Salmonella; Programmed cell death; Immune system; Apoptosis; Immunology; Inflammation; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002052699,0.0002902297,0.0003071524,0.00007976747,0.00009807113,0.00003079421,0.0002812089,0.0002802939,0.0000788367],"category_scores_gemma":[0.0001343516,0.0002865575,0.0002131827,0.0001087524,0.0001667248,0.00001354189,0.0001823724,0.0001171066,0.00004789352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002100406,"about_ca_system_score_gemma":0.0001323998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004142737,"about_ca_topic_score_gemma":0.00005392138,"domain_scores_codex":[0.9984582,0.0001368263,0.0004520726,0.000414815,0.0001306924,0.000407366],"domain_scores_gemma":[0.9989912,0.00003866948,0.0002614544,0.0004719814,0.0001481692,0.00008850908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002068316,0.0001163127,0.001414575,0.00005349797,0.00003462705,0.000002843259,0.0001460442,0.00002000402,0.9959145,0.00001035307,0.0007508873,0.001329494],"study_design_scores_gemma":[0.001324596,0.0003030016,0.002361318,0.00002709132,0.0000317036,0.000004872319,0.00009145265,0.00001381226,0.9169131,0.000005281623,0.07862141,0.000302373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977813,0.0002281758,0.000269786,0.00007192753,0.0004399013,0.0002328671,0.0001051827,0.00001820638,0.0008526001],"genre_scores_gemma":[0.9971997,0.0003033611,0.0002720302,0.0002708944,0.0005202974,0.00002021546,0.001073793,0.00005109345,0.0002885936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07900144,"threshold_uncertainty_score":0.9999586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00434469465684373,"score_gpt":0.1958256616587479,"score_spread":0.1914809670019042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}