{"id":"W1970837608","doi":"10.1016/j.chom.2014.07.002","title":"Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens","year":2014,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":440,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Inflammasome; Biology; Salmonella enterica; Innate immune system; Intestinal epithelium; Caspase 1; Microbiology; Proinflammatory cytokine; Caspase; Cell biology; Intracellular; Pyroptosis; Epithelium; Salmonella; Programmed cell death; Immune system; Apoptosis; Immunology; Inflammation; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000728284,0.0006568891,0.0005449103,0.0005422095,0.0004364024,0.001127673,0.0004824476,0.0007401853,0.00319464],"category_scores_gemma":[0.0004881004,0.0003001862,0.0007001651,0.0002506834,0.0008081983,0.001456537,0.0009383686,0.001737539,0.0008685879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008616906,"about_ca_system_score_gemma":0.0005810725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000165878,"about_ca_topic_score_gemma":0.0002337081,"domain_scores_codex":[0.9993248,0.0001527434,0.00009361893,0.0001253757,0.0001233808,0.0001800417],"domain_scores_gemma":[0.9995896,0.00003464472,0.0001435626,0.00004853265,0.00008466424,0.00009889167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00185182,0.0001102039,0.003205519,0.0003201729,0.00004490053,0.001008773,0.0000996577,0.0002354896,0.9842324,0.002499341,0.000353362,0.006038228],"study_design_scores_gemma":[0.0002211646,0.0007163444,0.02498847,0.00007379339,0.0001044237,0.00593484,0.0004220209,0.003323433,0.9514459,0.003661481,0.00907389,0.0000342283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607143,0.01643271,0.01555071,0.001577524,0.0003427847,0.0001020769,0.0006661026,0.0002315912,0.004382214],"genre_scores_gemma":[0.9892257,0.002920128,0.003983586,0.0001554615,0.0000612603,0.00004027865,0.0003296654,0.00002312077,0.003260868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00319464,"threshold_uncertainty_score":0.01068711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00434469465684373,"score_gpt":0.1958256616587479,"score_spread":0.1914809670019042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}