{"id":"W1970841589","doi":"10.1016/j.tet.2006.10.079","title":"Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin—synthesis of ring I mimetics","year":2006,"lang":"en","type":"article","venue":"Tetrahedron","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Paromomycin; Chemistry; Stereochemistry; Ring (chemistry); Ribosomal RNA; Protein subunit; Biochemistry; Aminoglycoside; Antibiotics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003419652,0.0002623796,0.000304801,0.000146549,0.0001715679,0.0002437361,0.0003555018,0.0003791266,0.0008836014],"category_scores_gemma":[0.0003128177,0.0001348554,0.0001949932,0.0001322117,0.0002895383,0.0002073403,0.0001651985,0.000609413,0.0002526423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004006416,"about_ca_system_score_gemma":0.0001850176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003864814,"about_ca_topic_score_gemma":0.0005005498,"domain_scores_codex":[0.9998417,0.00005088747,0.00001261656,0.00003175901,0.00002621029,0.00003673566],"domain_scores_gemma":[0.9997683,0.00008114024,0.0000659112,0.00003076988,0.00001630488,0.00003753348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003044606,0.00001627335,0.00005993259,0.00002455485,0.000002517365,0.00005467384,0.00002575936,0.0002302303,0.9980355,0.0003878633,0.00002696761,0.0008313151],"study_design_scores_gemma":[0.00002857292,0.0004253481,0.0002239003,0.000002653547,0.000006575815,0.00007499794,0.00001639597,0.0005156408,0.9976699,0.00006607533,0.0009655841,0.000004486964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911158,0.0005117002,0.005428696,0.0001004635,0.00003444229,0.00004468339,0.0001112446,0.00007040661,0.002582551],"genre_scores_gemma":[0.9952729,0.000284684,0.00339211,0.00004140925,0.000009234297,0.0000255353,0.00009964637,0.00002304089,0.0008513799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008836014,"threshold_uncertainty_score":0.002955973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008932560273244666,"score_gpt":0.2002370154271494,"score_spread":0.1913044551539048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}