{"id":"W1970862339","doi":"10.1046/j.1442-2042.2001.00311.x","title":"Novel therapeutic strategy for advanced prostate cancer using antisense oligodeoxynucleotides targeting anti‐apoptotic genes upregulated after androgen withdrawal to delay androgen‐independent progression and enhance chemosensitivity","year":2001,"lang":"en","type":"review","venue":"International Journal of Urology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Prostate cancer; Androgen; Medicine; Androgen receptor; LNCaP; Cancer research; Downregulation and upregulation; Cytotoxic T cell; Prostate; Internal medicine; Chemotherapy; Oncology; Cancer; Gene; Biology; Hormone; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003293879,0.0003697507,0.0007347435,0.000182616,0.0000756085,0.00006353659,0.0002066924,0.0003490808,0.00000995305],"category_scores_gemma":[0.00003253618,0.0002940513,0.0002699578,0.00009301991,0.00007132649,0.00002312227,0.0001281087,0.0001836362,4.913342e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006395116,"about_ca_system_score_gemma":0.0002508632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006779009,"about_ca_topic_score_gemma":0.00001539504,"domain_scores_codex":[0.9981307,0.00009872582,0.0007199964,0.0004664853,0.0002687322,0.0003153595],"domain_scores_gemma":[0.9982345,0.00003348903,0.0008529666,0.000137375,0.0006169569,0.0001247766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007324393,0.0001061663,0.0001030628,0.0003131339,0.0007275203,0.0001035857,0.00003390276,0.003102387,0.2263961,0.000007371646,0.000006438961,0.7683679],"study_design_scores_gemma":[0.007980445,0.004968708,0.000822363,0.00811702,0.004306341,0.02492386,0.00009028361,0.007812572,0.1985241,0.0003450136,0.7388198,0.003289505],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2621366,0.7278256,0.008659779,0.00005909063,0.0005931525,0.0006359639,0.00008199627,0.000005354346,0.00000248112],"genre_scores_gemma":[0.297914,0.6987132,0.002591757,0.00007434798,0.0004965891,0.00003123204,0.00008211752,0.00005790481,0.0000387706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7650784,"threshold_uncertainty_score":0.9999512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995785227462346,"score_gpt":0.3435117671013294,"score_spread":0.3235539148267059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}