{"id":"W1970874560","doi":"10.1152/ajpheart.00841.2007","title":"Peroxynitrite inhibits the expression of G<sub>i</sub>α protein and adenylyl cyclase signaling in vascular smooth muscle cells","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Adenylyl cyclase; Peroxynitrite; Gs alpha subunit; Forskolin; Chemistry; cGMP-dependent protein kinase; Soluble guanylyl cyclase; Vascular smooth muscle; Protein kinase A; Signal transduction; ADCY10; GTPgammaS; Internal medicine; Endocrinology; G protein; Phosphorylation; Protein kinase C; Nitric oxide; cAMP-dependent pathway; Biochemistry; Biology; Receptor; Mitogen-activated protein kinase kinase; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850048,0.0003618309,0.0002967641,0.0001140299,0.0001271493,0.0002061015,0.0001228233,0.0002438033,0.0008566803],"category_scores_gemma":[0.0001621729,0.0001090453,0.0002368287,0.00008462717,0.0002574329,0.000168851,0.0001951221,0.0005216251,0.0001742995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312349,"about_ca_system_score_gemma":0.0002468671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000848381,"about_ca_topic_score_gemma":0.001085763,"domain_scores_codex":[0.9998899,0.00002829931,0.000009060182,0.00001639401,0.0000142459,0.00004212413],"domain_scores_gemma":[0.9999099,0.00001707161,0.00002364981,0.00001054506,0.00001192669,0.00002694986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003370139,0.00004583771,0.00009890507,0.00003331528,0.000005246058,0.00004505727,0.00001981899,0.00002509485,0.998418,0.00005621389,0.0000317819,0.0008836584],"study_design_scores_gemma":[0.0000920402,0.001856986,0.006170754,0.00001237469,0.00002012413,0.0002260589,0.00008599962,0.0008136436,0.988301,0.00009601969,0.002320881,0.000004106817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958935,0.001841421,0.00092509,0.000146369,0.00005041438,0.00002238076,0.00006051699,0.00004482811,0.001015469],"genre_scores_gemma":[0.9955329,0.001315299,0.0007800307,0.0001224725,0.00002681746,0.00003046915,0.0001983239,0.00001222822,0.001981464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008566803,"threshold_uncertainty_score":0.002865851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007918302738217127,"score_gpt":0.2302657787137533,"score_spread":0.2223474759755362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}