{"id":"W1970912888","doi":"10.4236/jibtva.2013.21002","title":"Challenges on Induction of Broadly Neutralizing Antibodies for Optimization of HIV Vaccines Development and Vectored Immunoprophylaxis","year":2013,"lang":"en","type":"article","venue":"Journal of Immune Based Therapies Vaccines and Antimicrobials","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Virology; Human immunodeficiency virus (HIV); HIV vaccine; AIDS Vaccines; Antibody; Immunology; Medicine; Antibody response; Viral vector; Biology; Vaccine trial; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003512857,0.0004582579,0.0006529214,0.000411095,0.0002079846,0.001573433,0.0006857785,0.0007847049,0.002143105],"category_scores_gemma":[0.001865258,0.0003833029,0.0003988842,0.000348092,0.0005800903,0.001116316,0.0005434119,0.002167107,0.001251498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006855626,"about_ca_system_score_gemma":0.0009659174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004091051,"about_ca_topic_score_gemma":0.0006279016,"domain_scores_codex":[0.9984713,0.000698112,0.0001537692,0.0001339405,0.0004428574,0.00009987559],"domain_scores_gemma":[0.9989225,0.0004774078,0.0001646505,0.0001006854,0.0002633673,0.00007143286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002722044,0.0004883719,0.0008391652,0.001679516,0.00004571524,0.0001630522,0.0001717952,0.004155301,0.7651775,0.01381808,0.002664041,0.2105252],"study_design_scores_gemma":[0.0001429167,0.004409222,0.0026882,0.0008552219,0.0001352564,0.001610728,0.0004540246,0.009557128,0.6961884,0.01134847,0.2725253,0.00008518179],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3109522,0.2535313,0.3904293,0.01834694,0.001703881,0.002226629,0.001465347,0.0009862084,0.02035806],"genre_scores_gemma":[0.4822785,0.1467605,0.3564119,0.002684687,0.0004750476,0.001281681,0.001365796,0.0002386849,0.008503167],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003512857,"threshold_uncertainty_score":0.01857799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243722035060385,"score_gpt":0.2582450432350303,"score_spread":0.2338728397289918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}