{"id":"W1970924175","doi":"10.1210/endo.142.1.7908","title":"Somatostatin Inhibits Akt Phosphorylation and Cell CycleEntry, But Not p42/p44 Mitogen-Activated Protein (MAP) KinaseActivation in Normal and Tumoral Pancreatic Acinar Cells**This research was supported by Grant 970384 (to N.R.) from the Natural Sciences and Engineering Research Council of Canada.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Endocrinology; Internal medicine; Protein kinase B; Kinase; Biology; Pancreas; Epidermal growth factor; Mitogen-activated protein kinase; Cyclin-dependent kinase; Somatostatin; Cyclin D; Cyclin-dependent kinase 4; Cyclin-dependent kinase 2; Cell biology; Cell growth; Cancer research; Protein kinase A; Phosphorylation; Cell cycle; Cell culture; Cell; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009741385,0.0001900536,0.0003276957,0.0002667124,0.0002596132,0.00003409017,0.0001186127,0.00009719903,0.00002357166],"category_scores_gemma":[0.0008037485,0.0001621561,0.00001602894,0.0007420448,0.0004187691,0.0001172194,0.00016179,0.0008239498,0.000001529089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007312901,"about_ca_system_score_gemma":0.00172569,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2431365,"about_ca_topic_score_gemma":0.04380981,"domain_scores_codex":[0.9969018,0.0002884273,0.000363707,0.0005096635,0.00115709,0.0007793214],"domain_scores_gemma":[0.9985569,0.0005027889,0.00008743329,0.0002198625,0.0004678546,0.0001651372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007104818,0.00005004834,0.005310019,0.00007354588,0.00002430965,0.0001608997,0.001728056,0.00002619559,0.9904295,0.00003530388,0.0008384313,0.0006131614],"study_design_scores_gemma":[0.002125314,0.0004188577,0.02054051,0.0001895143,0.00001386858,0.00008580915,0.001230133,0.001526832,0.9719484,0.00002303569,0.001749863,0.0001478903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943219,0.002103665,0.00001136129,0.002111278,0.00009715007,0.001170298,0.0000575554,0.00002078928,0.0001060118],"genre_scores_gemma":[0.9992204,0.000150796,0.0001952748,0.00005837518,0.00003134403,0.00008313612,0.00003595367,0.00002430327,0.0002003818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1993267,"threshold_uncertainty_score":0.9736382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03863678276005483,"score_gpt":0.2724818347023182,"score_spread":0.2338450519422633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}