{"id":"W1970924175","doi":"10.1210/endo.142.1.7908","title":"Somatostatin Inhibits Akt Phosphorylation and Cell CycleEntry, But Not p42/p44 Mitogen-Activated Protein (MAP) KinaseActivation in Normal and Tumoral Pancreatic Acinar Cells**This research was supported by Grant 970384 (to N.R.) from the Natural Sciences and Engineering Research Council of Canada.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Endocrinology; Internal medicine; Protein kinase B; Kinase; Biology; Pancreas; Epidermal growth factor; Mitogen-activated protein kinase; Cyclin-dependent kinase; Somatostatin; Cyclin D; Cyclin-dependent kinase 4; Cyclin-dependent kinase 2; Cell biology; Cell growth; Cancer research; Protein kinase A; Phosphorylation; Cell cycle; Cell culture; Cell; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008901724,0.0003734989,0.0001906669,0.0002105887,0.0001148344,0.0001907058,0.0001237963,0.000143961,0.001237028],"category_scores_gemma":[0.00008999442,0.00009396876,0.0002257246,0.0001255662,0.0001727166,0.0001210552,0.0001123305,0.0003047359,0.0003363324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001908909,"about_ca_system_score_gemma":0.0002219389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007551386,"about_ca_topic_score_gemma":0.001522712,"domain_scores_codex":[0.9999213,0.00001297745,0.0000102999,0.00001016316,0.00002162421,0.00002365951],"domain_scores_gemma":[0.9999286,0.00001760698,0.00001659184,0.00000820281,0.000006539214,0.00002249413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002507928,0.00004047695,0.0001351814,0.00003608791,0.000003244519,0.0000429707,0.000007723083,0.00003015744,0.9981732,0.0000282298,0.00002728765,0.001224612],"study_design_scores_gemma":[0.0000444953,0.00114178,0.005044005,0.000002708723,0.00001235437,0.0001997851,0.00001957477,0.0003166588,0.9913037,0.00001737523,0.001894609,0.000002795141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962174,0.001719341,0.0002934797,0.00003782989,0.00002425082,0.00001447296,0.0002100281,0.0000387794,0.001444309],"genre_scores_gemma":[0.9940571,0.001582152,0.000649887,0.00003208358,0.00001921593,0.00003043156,0.0007415296,0.0000154438,0.002872237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237028,"threshold_uncertainty_score":0.004138291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03863678276005483,"score_gpt":0.2724818347023182,"score_spread":0.2338450519422633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}