{"id":"W1970940394","doi":"10.1016/s0143416002001550","title":"Ca2+-calmodulin regulates receptor-operated Ca2+ entry activity of TRPC6 in HEK-293 cells","year":2002,"lang":"en","type":"article","venue":"Cell Calcium","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"TRPC6; Thapsigargin; TRPC; Transient receptor potential channel; Calmodulin; Cell biology; HEK 293 cells; Chemistry; Trifluoperazine; Agonist; Receptor; Transfection; Biophysics; Intracellular; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001928042,0.0002756745,0.0003946745,0.0001692099,0.0001114795,0.00003505256,0.0003399742,0.0002530445,0.002267237],"category_scores_gemma":[0.00009758303,0.0002401707,0.000135072,0.0006746024,0.0002097844,0.0001820311,0.0001042797,0.0003733465,0.0005147831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009979744,"about_ca_system_score_gemma":0.00003465705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001659483,"about_ca_topic_score_gemma":0.00001039459,"domain_scores_codex":[0.9978119,0.0002813845,0.0003960449,0.0006153753,0.0003504182,0.0005448411],"domain_scores_gemma":[0.9991148,0.0001806096,0.0001617865,0.0003135981,0.00005581565,0.0001734337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004454197,0.0004715408,0.00006811559,0.00005728407,0.00000210279,0.00001609439,0.0006194687,0.0006292085,0.9875968,0.00001943341,0.009561733,0.000913646],"study_design_scores_gemma":[0.0007350429,0.000104114,0.00009449788,0.00003744248,0.000005886372,0.000003765773,0.00007624182,0.007142352,0.9845356,0.00001462208,0.006971984,0.0002784569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988405,0.000166608,0.00003808854,0.0003128782,0.00169539,0.0003138026,0.00004010215,0.00007293261,0.008955233],"genre_scores_gemma":[0.9828965,0.0002683245,0.00005133927,0.000175735,0.0001686682,0.0000133006,0.00000383455,0.00003847411,0.01638381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007428579,"threshold_uncertainty_score":0.9986448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158933686617024,"score_gpt":0.2479126198075479,"score_spread":0.2063232829413777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}