{"id":"W1970969296","doi":"10.1158/1535-7163.mct-07-2444","title":"Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Bortezomib; Head and neck squamous-cell carcinoma; Cisplatin; Proteasome inhibitor; Cancer research; Apoptosis; Programmed cell death; Cancer cell; Small interfering RNA; Cancer; Chemistry; Chemotherapy; Head and neck cancer; Medicine; Biology; Cell culture; Internal medicine; Transfection; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424949,0.000497346,0.0005872482,0.0003799501,0.0002317593,0.0002294618,0.0001872021,0.0001811849,0.001242025],"category_scores_gemma":[0.00008841734,0.0002361027,0.0003250789,0.0003012998,0.0001546648,0.000204782,0.0003247258,0.0005623485,0.0004315307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002856568,"about_ca_system_score_gemma":0.0003982491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004851577,"about_ca_topic_score_gemma":0.00123679,"domain_scores_codex":[0.9998123,0.00003477711,0.00002733647,0.00002392265,0.00005916831,0.00004256709],"domain_scores_gemma":[0.9999608,0.000004728859,0.000006014033,0.0000058259,0.000005531729,0.00001727903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007532818,0.0002069047,0.0003512664,0.0001546476,0.00002510321,0.0001168001,0.00003010134,0.0002294391,0.9903097,0.0001348534,0.0003277536,0.007360138],"study_design_scores_gemma":[0.0002743436,0.002315271,0.01106661,0.00001563439,0.00004631296,0.000679067,0.00003954186,0.001498718,0.9758672,0.00009448015,0.008087144,0.00001563901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871414,0.00694336,0.001196555,0.0001921301,0.0001133744,0.0001352674,0.0004667105,0.0001763935,0.003634857],"genre_scores_gemma":[0.9916015,0.002694063,0.001556142,0.0001027807,0.00002125601,0.0001998733,0.0008076087,0.00001385333,0.003002793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001242025,"threshold_uncertainty_score":0.004154921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403573098676502,"score_gpt":0.2322990722071788,"score_spread":0.2182633412204138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}