{"id":"W1970990464","doi":"10.1016/j.reprotox.2012.11.006","title":"Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase","year":2012,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Hospital for Sick Children","keywords":"Catalase; Genetically modified mouse; Reactive oxygen species; Embryo; Endogeny; Chemistry; Endocrinology; Mutant; Transgene; Internal medicine; Enzyme; Biochemistry; Biology; Pharmacology; Medicine; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009131941,0.0003361045,0.0006199227,0.0002227873,0.0001336355,0.00001496864,0.0001110612,0.0001894298,0.00002540298],"category_scores_gemma":[0.000311269,0.0002851857,0.00006478818,0.000410142,0.0003888417,0.0004188272,0.00008926183,0.0005479156,0.00001175669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003501439,"about_ca_system_score_gemma":0.0001151203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002136199,"about_ca_topic_score_gemma":0.000426164,"domain_scores_codex":[0.9973345,0.0003885083,0.0002934724,0.0009994716,0.0002469962,0.0007370169],"domain_scores_gemma":[0.9986299,0.000182073,0.0001607944,0.0006723278,0.00008049091,0.0002743848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001067928,0.001012862,0.03265216,0.000142952,0.00009215518,0.0001016734,0.003431362,0.000008467619,0.9599953,0.00004722928,0.00001926523,0.001428655],"study_design_scores_gemma":[0.001915706,0.0006001606,0.1712568,0.00008678264,0.0001329731,0.0007842476,0.0001724604,0.00001355335,0.8246374,0.00001503594,0.0001273239,0.0002576031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956818,0.001980955,0.0001989151,0.0003674943,0.000227813,0.001224753,0.00002299791,0.00008040007,0.0002149127],"genre_scores_gemma":[0.9985669,0.00001333355,0.0007443898,0.0001047209,0.0002995264,0.0001365651,0.00002134274,0.00004620284,0.00006704978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1386046,"threshold_uncertainty_score":0.99996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230414020381924,"score_gpt":0.2897368214450963,"score_spread":0.2674326812412771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}