{"id":"W1971014753","doi":"10.1089/hum.2013.169","title":"Immune Responses to Intramuscular Administration of Alipogene Tiparvovec (AAV1-LPL <sup>S447X</sup> ) in a Phase II Clinical Trial of Lipoprotein Lipase Deficiency Gene Therapy","year":2013,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"University of Washington","keywords":"Immune system; Genetic enhancement; Lipoprotein lipase; Transgene; Immunology; Systemic administration; CD8; Intramuscular injection; Medicine; Biology; Pharmacology; Internal medicine; Gene; In vivo; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00237884,0.0004620017,0.0008052705,0.0003479056,0.0001692702,0.00004434092,0.0008672472,0.0004159798,0.0005658811],"category_scores_gemma":[0.0001824727,0.0004297838,0.0004599419,0.000483,0.0003556125,0.0000210345,0.0001589677,0.0002787509,0.0000265112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004158204,"about_ca_system_score_gemma":0.0005471245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002949844,"about_ca_topic_score_gemma":0.0001305684,"domain_scores_codex":[0.9950526,0.001090182,0.001699144,0.0008764499,0.0006223221,0.0006593266],"domain_scores_gemma":[0.9972746,0.00007172429,0.0004377925,0.001577581,0.0003801006,0.0002581793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1346354,0.003586407,0.00007334642,0.00001284518,0.0001539201,0.000008273874,0.0003559403,0.0001133161,0.8109895,0.00001404464,0.000130745,0.04992625],"study_design_scores_gemma":[0.0475054,0.07654607,0.0008570006,0.00002129698,0.00001125466,0.000009546015,0.00006884351,0.00006840164,0.8731369,0.0001318435,0.001258571,0.0003849124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912389,0.004795063,0.0001569679,0.0002541718,0.00009270634,0.003310435,0.00005764821,0.00002310199,0.0000710353],"genre_scores_gemma":[0.9939059,0.003289296,0.0008666239,0.0002825164,0.00051009,0.0005328888,0.0002061416,0.00009315116,0.0003134078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08713003,"threshold_uncertainty_score":0.9998154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06795032400591136,"score_gpt":0.3955811293289452,"score_spread":0.3276308053230339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}