{"id":"W1971014753","doi":"10.1089/hum.2013.169","title":"Immune Responses to Intramuscular Administration of Alipogene Tiparvovec (AAV1-LPL <sup>S447X</sup> ) in a Phase II Clinical Trial of Lipoprotein Lipase Deficiency Gene Therapy","year":2013,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"University of Washington","keywords":"Immune system; Genetic enhancement; Lipoprotein lipase; Transgene; Immunology; Systemic administration; CD8; Intramuscular injection; Medicine; Biology; Pharmacology; Internal medicine; Gene; In vivo; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008711831,0.0008705093,0.001061396,0.0002557527,0.0002620831,0.0005876743,0.0002632526,0.0009946523,0.001157794],"category_scores_gemma":[0.0002315954,0.0002656892,0.0003227591,0.0001366995,0.0006105141,0.0002988073,0.0001866503,0.001360638,0.0003384636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000406835,"about_ca_system_score_gemma":0.0004937518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565589,"about_ca_topic_score_gemma":0.0005497697,"domain_scores_codex":[0.9997026,0.0001107823,0.00001406676,0.00004872997,0.00003815758,0.00008562185],"domain_scores_gemma":[0.9998179,0.00003300661,0.0000391108,0.00001329708,0.00001543622,0.00008128437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1498016,0.06669744,0.007052786,0.0004369733,0.0002604568,0.0006864768,0.0003730774,0.001748786,0.6911267,0.0002949691,0.00117567,0.080345],"study_design_scores_gemma":[0.04463983,0.8817114,0.01076024,0.00001825413,0.0001508449,0.0004220811,0.00006669522,0.001513449,0.05879434,0.00006156569,0.001843427,0.00001786589],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998356,0.0003633455,0.0002766045,0.00005650569,0.00002274808,0.000401253,0.00005635952,0.00003203117,0.0004351259],"genre_scores_gemma":[0.996196,0.0003155571,0.000711687,0.0001742898,0.00006170414,0.0007639345,0.0002803723,0.000008918841,0.001487466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157794,"threshold_uncertainty_score":0.00460732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06795032400591136,"score_gpt":0.3955811293289452,"score_spread":0.3276308053230339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}