{"id":"W1971032837","doi":"10.1038/ncb1792","title":"Tethering by lamin A stabilizes and targets the ING1 tumour suppressor","year":2008,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Lamin; LMNA; Chromatin; Cell biology; Biology; Progeria; Histone acetyltransferase; Histone deacetylase; Histone; Phenotype; Genetics; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799413,0.0003091213,0.0002502543,0.0003706711,0.0006535352,0.0007037394,0.0004685428,0.0005164896,0.002740602],"category_scores_gemma":[0.0002946415,0.0002688502,0.0002545794,0.0001571811,0.0003756709,0.0004113043,0.0007317003,0.0007546483,0.001863885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007640353,"about_ca_system_score_gemma":0.0002244303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008357287,"about_ca_topic_score_gemma":0.001382341,"domain_scores_codex":[0.9998143,0.00002066916,0.00000907096,0.00004277794,0.0000601608,0.00005303303],"domain_scores_gemma":[0.9997273,0.00004592212,0.00008330288,0.00004829549,0.00002032728,0.00007472978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478839,0.0000280213,0.0003363565,0.00002658877,0.000008783555,0.0001194384,0.00003215705,0.0002461383,0.9952301,0.0005483692,0.0003091716,0.002967055],"study_design_scores_gemma":[0.00001103005,0.00007567927,0.002144755,0.000003734664,0.00001093531,0.0002547916,0.0000525363,0.001104863,0.9890642,0.0002499864,0.00701712,0.00001036017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924252,0.001479866,0.002183902,0.0002713681,0.00007766327,0.000007371641,0.000092875,0.0003612699,0.003100502],"genre_scores_gemma":[0.9939198,0.0002753234,0.000436605,0.00008466686,0.00001790019,0.000007504556,0.0001773828,0.00007492767,0.005005877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002740602,"threshold_uncertainty_score":0.009168208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003278577585588061,"score_gpt":0.2017166936743409,"score_spread":0.1984381160887528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}