{"id":"W1971040062","doi":"10.1371/journal.pone.0106449","title":"G-Quadruplex Structures Formed by Expanded Hexanucleotide Repeat RNA and DNA from the Neurodegenerative Disease-Linked C9orf72 Gene Efficiently Sequester and Activate Heme","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"RNA; Trinucleotide repeat expansion; DNA; C9orf72; Biology; Heme; Cell biology; Gene; Sense (electronics); Biochemistry; Molecular biology; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008115403,0.0002468238,0.0002191446,0.00001098026,0.0001753415,0.00008632526,0.0001915248,0.0001149916,0.00001963615],"category_scores_gemma":[0.000156475,0.0001831431,0.00004710435,0.00003552212,0.000194881,0.00001055006,0.00020603,0.0001291674,0.000001746376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000969776,"about_ca_system_score_gemma":0.00002049121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001505983,"about_ca_topic_score_gemma":0.000006981169,"domain_scores_codex":[0.9987196,0.00008045821,0.0001912566,0.0005472969,0.000197912,0.0002634281],"domain_scores_gemma":[0.9991162,0.00004953414,0.00009981449,0.0004830637,0.00005618418,0.000195198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001877539,0.0001289653,0.002799334,0.00002493554,0.000138462,0.000002039636,0.00007890792,0.00000193021,0.995387,0.000009778526,0.0008484408,0.0003925174],"study_design_scores_gemma":[0.0009462623,0.0001019532,0.008042725,0.00002400084,0.0001019277,0.00000208506,0.00003718415,0.0002998847,0.98917,0.000240144,0.0007866383,0.0002471861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979362,0.0008081697,0.0001129753,0.0005540391,0.00003341849,0.000210833,0.0001561258,0.00002518462,0.0001630313],"genre_scores_gemma":[0.9969515,0.0002652781,0.0004589589,0.001129908,0.0003213617,0.00002142545,0.0003982236,0.0000381126,0.0004152351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006216926,"threshold_uncertainty_score":0.7468361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469909483951743,"score_gpt":0.2042260930119265,"score_spread":0.1895269981724091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}