{"id":"W1971040886","doi":"10.1038/nrc726","title":"Modifiers of risk of hereditary breast and ovarian cancer","year":2002,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Women's College Hospital","funders":"","keywords":"Medicine; Breast cancer; Ovarian cancer; Disease; Gynecology; Cancer; Hereditary Cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006271014,0.001215186,0.001874796,0.001370103,0.0002221288,0.0006297226,0.001573935,0.001552673,0.004035302],"category_scores_gemma":[0.0009450247,0.0003303854,0.0004013536,0.001487504,0.000564187,0.0005073538,0.0005045093,0.001379431,0.002279097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005552298,"about_ca_system_score_gemma":0.0005754387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412087,"about_ca_topic_score_gemma":0.002302801,"domain_scores_codex":[0.9997655,0.00004666571,0.00002173104,0.00004396604,0.00009811389,0.00002408474],"domain_scores_gemma":[0.9996325,0.0001910316,0.00005492048,0.00001439445,0.0000738675,0.00003324168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002398934,0.00008486667,0.0012462,0.005690747,0.0002433516,0.0007157106,0.00003934573,0.000469283,0.003524666,0.003844905,0.0690984,0.9148028],"study_design_scores_gemma":[0.00009812637,0.0001339976,0.009008925,0.002510589,0.0004215381,0.00396353,0.00006873046,0.0001176951,0.001604023,0.004189875,0.9778505,0.00003245198],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003115319,0.9970112,0.0002898847,0.0006164483,0.0003478205,0.000005746135,0.00005836516,0.00002078408,0.001338255],"genre_scores_gemma":[0.001632025,0.9966522,0.0002747536,0.0002484918,0.0003067183,0.00001232231,0.00006656416,0.000001955659,0.0008049787],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004035302,"threshold_uncertainty_score":0.01349938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238707658490207,"score_gpt":0.3401112104186964,"score_spread":0.3177241338337943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}