{"id":"W1971040886","doi":"10.1038/nrc726","title":"Modifiers of risk of hereditary breast and ovarian cancer","year":2002,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Women's College Hospital","funders":"","keywords":"Medicine; Breast cancer; Ovarian cancer; Disease; Gynecology; Cancer; Hereditary Cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000342569,0.0005088637,0.001914316,0.0001219856,0.00004636989,0.000008527858,0.0004097222,0.001231758,0.0002346875],"category_scores_gemma":[0.0001376254,0.0003980293,0.0005467378,0.0004019006,0.0002095201,0.000005472334,0.0001400217,0.0007790283,0.000002960464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514519,"about_ca_system_score_gemma":0.0006036022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002402593,"about_ca_topic_score_gemma":0.0001890061,"domain_scores_codex":[0.9976415,0.0002818507,0.0009049727,0.0006741046,0.0002336919,0.0002638472],"domain_scores_gemma":[0.9976115,0.00004752676,0.001244854,0.0007738992,0.0002218966,0.0001003611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000106647,0.00002429702,0.00004033558,0.01567482,0.0005510977,0.000001176626,0.00002721812,0.000008727134,0.00002583064,0.00001550376,0.02160802,0.9620123],"study_design_scores_gemma":[0.000231755,0.00003155803,0.00003316082,0.01017409,0.001831854,0.0000488841,0.000005420036,0.000003040715,0.00006760335,0.00001239631,0.9872012,0.0003590631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002898038,0.9943926,0.00002607371,0.00003404095,0.000845965,0.0008870312,0.00342825,0.000005695624,0.0003513513],"genre_scores_gemma":[0.0001279399,0.9971381,0.0006206977,0.00007703545,0.0009893313,0.0004528089,0.0002195349,0.00007969596,0.0002948473],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9655932,"threshold_uncertainty_score":0.9998472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238707658490207,"score_gpt":0.3401112104186964,"score_spread":0.3177241338337943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}