{"id":"W1971045545","doi":"10.1371/journal.pgen.1000407","title":"Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Mitochondrial biogenesis; Mitochondrion; Phenotype; Biogenesis; Gene; Genetics; Genetic screen; Mitochondrial DNA; Mitochondrial disease; Mutant; Proteomics; Computational biology; Saccharomyces cerevisiae; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001508337,0.0008483838,0.0006027501,0.0003654426,0.0003076618,0.0008388626,0.0009422922,0.0005500577,0.001087095],"category_scores_gemma":[0.003609331,0.0003290896,0.0007353352,0.0004537937,0.0007219253,0.0005481686,0.0003740856,0.0008581374,0.0001655904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066394,"about_ca_system_score_gemma":0.001248727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001881374,"about_ca_topic_score_gemma":0.003293036,"domain_scores_codex":[0.9995158,0.000159346,0.00002631473,0.0001187188,0.0001433828,0.00003644735],"domain_scores_gemma":[0.9978124,0.001734981,0.0001151757,0.0001677638,0.0001239218,0.00004572104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001000695,0.0006166427,0.01700018,0.0004653296,0.0002708979,0.0002217326,0.00006852069,0.8541596,0.08495417,0.01136877,0.001245962,0.02862759],"study_design_scores_gemma":[0.0000430341,0.00008616071,0.001255254,0.000002800238,0.0000276503,0.00002392665,0.00001364696,0.9826998,0.01243338,0.003063766,0.0003414637,0.000009205106],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8294111,0.0002057818,0.1625555,0.0004321901,0.00005985382,0.0001021944,0.001727028,0.002911728,0.002594642],"genre_scores_gemma":[0.8924179,0.0001018499,0.1048086,0.0001167343,0.000008205894,0.0001892023,0.001846419,0.0001095607,0.000401448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001881374,"threshold_uncertainty_score":0.007976949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372101719117413,"score_gpt":0.3101332694805154,"score_spread":0.2664122522893413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}