{"id":"W1971066362","doi":"10.1523/jneurosci.0877-06.2006","title":"Transient Receptor Potential Vanilloid 1 Is Required for Intrinsic Osmoreception in Organum Vasculosum Lamina Terminalis Neurons and for Normal Thirst Responses to Systemic Hyperosmolality","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Transient receptor potential channel; Lamina terminalis; Osmoreceptor; TRPC; TRPV; Subfornical organ; Internal medicine; Neuroscience; TRPV1; Transduction (biophysics); Endocrinology; Biology; Cell biology; Mechanosensation; Chemistry; Thirst; Receptor; Biophysics; Central nervous system; Ion channel; Angiotensin II; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145826,0.0003296244,0.0003538022,0.000332351,0.0002213828,0.0005157558,0.0003306602,0.0005545013,0.001120973],"category_scores_gemma":[0.0004857599,0.0002912501,0.0003461186,0.0001299166,0.0005034716,0.0004004618,0.0003867161,0.0009132595,0.0002772771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004745624,"about_ca_system_score_gemma":0.0002929815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007792777,"about_ca_topic_score_gemma":0.001151525,"domain_scores_codex":[0.9996511,0.0000314156,0.0000470673,0.00008214282,0.00008306418,0.0001052028],"domain_scores_gemma":[0.9993607,0.00007031487,0.000306638,0.00004435921,0.00003918803,0.0001788051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007571095,0.000009695049,0.0002787508,0.00002128385,0.000002044523,0.00008861312,0.00001345544,0.00002884751,0.999137,0.00006020244,0.000010225,0.0002742562],"study_design_scores_gemma":[0.00004155577,0.0003101312,0.05328023,0.0000262335,0.00002629038,0.001158389,0.000123422,0.001462437,0.9420418,0.0002107771,0.001300497,0.00001828807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971788,0.0006522414,0.001437863,0.0000674865,0.00001970998,0.000008492597,0.0002491728,0.00006788801,0.0003183027],"genre_scores_gemma":[0.997072,0.0003593464,0.001096385,0.00002949445,0.000008285529,0.00003277337,0.0003635136,0.00003135577,0.001006863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120973,"threshold_uncertainty_score":0.003750086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03306930988996613,"score_gpt":0.2797761946338268,"score_spread":0.2467068847438607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}