{"id":"W1971110677","doi":"10.1016/j.drup.2004.02.004","title":"New cancer therapeutics: target-specific in, cytotoxics out?","year":2004,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Cancer; Clinical trial; Biomarker; Medicine; Drug development; Proteomics; Targeted therapy; Biomarker discovery; Computational biology; Drug; Cancer research; Bioinformatics; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009000349,0.0002051387,0.0001743245,0.0000498019,0.00006133868,0.00004031004,0.000293787,0.0001301937,0.00005570279],"category_scores_gemma":[0.000006584309,0.0002009738,0.00008084909,0.0001163768,0.00005438034,0.000007437447,0.00006206375,0.0001291305,0.00003691981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006914083,"about_ca_system_score_gemma":0.0001792127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004981668,"about_ca_topic_score_gemma":0.004596759,"domain_scores_codex":[0.9988467,0.00002380987,0.0002420895,0.0004171884,0.0001203557,0.0003498694],"domain_scores_gemma":[0.9993787,0.000006032696,0.00007497851,0.0004073379,0.00005180921,0.00008111564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002188551,0.0001176208,0.003867042,0.00003499928,0.00007813434,0.00001385949,0.0005593497,0.0005486188,0.9652116,0.002091147,0.02496254,0.002296205],"study_design_scores_gemma":[0.0007807819,0.00001398414,0.0007388833,0.00004579612,0.000007582387,9.88407e-7,0.0001034547,0.000002912932,0.4615269,0.001643097,0.5348682,0.0002673456],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252902,0.05394362,0.01175055,0.003901512,0.0007451115,0.0005710445,0.0001181884,0.00006320898,0.003616597],"genre_scores_gemma":[0.9521315,0.01898093,0.01332249,0.001928266,0.0006141311,0.00006217672,0.000273578,0.0000829698,0.01260398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5099057,"threshold_uncertainty_score":0.8195472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008700666978959477,"score_gpt":0.2475809144283475,"score_spread":0.238880247449388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}