{"id":"W1971110677","doi":"10.1016/j.drup.2004.02.004","title":"New cancer therapeutics: target-specific in, cytotoxics out?","year":2004,"lang":"en","type":"article","venue":"Drug Resistance Updates","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Cancer; Clinical trial; Biomarker; Medicine; Drug development; Proteomics; Targeted therapy; Biomarker discovery; Computational biology; Drug; Cancer research; Bioinformatics; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004132567,0.0007036609,0.001873772,0.0007174922,0.0007862572,0.00296746,0.001129219,0.002752603,0.009456234],"category_scores_gemma":[0.003498666,0.0004627997,0.0006845066,0.0005973473,0.001593697,0.007510418,0.001003205,0.006174984,0.002435525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001181677,"about_ca_system_score_gemma":0.001111076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005955078,"about_ca_topic_score_gemma":0.002640838,"domain_scores_codex":[0.9992174,0.0001821956,0.0001147336,0.0001104467,0.0002714758,0.0001037489],"domain_scores_gemma":[0.9978127,0.0009438918,0.0001791411,0.0001641905,0.0007002331,0.0001997462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005550699,0.0002852354,0.001093628,0.002414416,0.000141715,0.0004881085,0.0003349734,0.0006508293,0.01764904,0.03249652,0.1408445,0.8030458],"study_design_scores_gemma":[0.0001821276,0.0007953704,0.00123292,0.0005329732,0.0002255447,0.001991739,0.00047814,0.0009225595,0.007268298,0.02636392,0.95994,0.00006655101],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.01870415,0.7020344,0.01605912,0.2140607,0.01598378,0.0001048338,0.000292439,0.0007719156,0.0319887],"genre_scores_gemma":[0.1172062,0.6685441,0.02036533,0.1260726,0.02876177,0.0001472242,0.0004312863,0.0003356113,0.03813595],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.009456234,"threshold_uncertainty_score":0.03163427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008700666978959477,"score_gpt":0.2475809144283475,"score_spread":0.238880247449388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}