{"id":"W1971123104","doi":"10.1006/jmbi.2000.3987","title":"Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase 1 1Edited by I. A. Wilson","year":2000,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"DNA ligase; Conformational change; Chemistry; Substrate (aquarium); SUPERFAMILY; Ubiquitin ligase; Stereochemistry; Peptide bond; Amide; Substrate specificity; Biochemistry; Biophysics; Biology; Enzyme; Ubiquitin; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156303,0.0002316484,0.0003811747,0.0001508143,0.0003568878,0.0005077503,0.0003790664,0.0005495596,0.00281451],"category_scores_gemma":[0.0002512043,0.0001196237,0.000312741,0.000142459,0.0003437787,0.0006041866,0.0002846693,0.0007921654,0.0008070121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00024392,"about_ca_system_score_gemma":0.0001466017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001359943,"about_ca_topic_score_gemma":0.0001299799,"domain_scores_codex":[0.9999392,0.00001014222,0.000003868173,0.00001789167,0.00001498199,0.00001394612],"domain_scores_gemma":[0.9998922,0.00001662062,0.00002535516,0.00001136364,0.00001163424,0.00004272488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008924745,0.0001790686,0.00282145,0.0001501688,0.00003032117,0.001857576,0.0001925561,0.0018644,0.9699244,0.009042517,0.000797009,0.01224805],"study_design_scores_gemma":[0.0007833118,0.004818429,0.1040468,0.0001464797,0.0002128676,0.01874558,0.001156706,0.02381272,0.7628391,0.02705331,0.05621309,0.0001716761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855168,0.004266982,0.004842109,0.0009451107,0.0001696748,0.00002394257,0.0001275044,0.00009690124,0.004010927],"genre_scores_gemma":[0.9938908,0.001155267,0.002000174,0.0003390893,0.0001069848,0.00002342277,0.0002866657,0.00001370777,0.002184015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00281451,"threshold_uncertainty_score":0.009415448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03060983509792516,"score_gpt":0.3093459389777219,"score_spread":0.2787361038797968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}