{"id":"W1971127923","doi":"10.1126/stke.2003.195.pe33","title":"MSK1 and MSK2 Mediate Mitogen- and Stress-Induced Phosphorylation of Histone H3: A Controversy Resolved","year":2003,"lang":"en","type":"review","venue":"Science s STKE","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Histone H3; Acetylation; Phosphorylation; Mitogen-activated protein kinase; Histone; Kinase; Cell biology; Signal transduction; MAPK/ERK pathway; Chemistry; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004201964,0.0002392297,0.0005404672,0.00009409414,0.000120957,0.00004017244,0.0002554024,0.0002152376,0.00000523928],"category_scores_gemma":[0.0001364215,0.0002103634,0.00009114801,0.0001892252,0.0004705642,0.000005898262,0.0001664461,0.0001060587,0.000001122569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004139254,"about_ca_system_score_gemma":0.0004677403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001847622,"about_ca_topic_score_gemma":0.00002844402,"domain_scores_codex":[0.9985737,0.00004609376,0.0003569789,0.0005563102,0.0002073751,0.0002595387],"domain_scores_gemma":[0.9990168,0.00002063334,0.0003516451,0.0003798814,0.0001074512,0.0001235803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003296643,0.0000910457,0.0001497725,0.004393708,0.0001727142,0.000005328933,0.0002396183,0.000004674331,0.1484941,0.0007855344,0.0002723816,0.8453581],"study_design_scores_gemma":[0.00158669,0.0007319408,0.0002818123,0.001907921,0.0006600675,0.00008329772,0.0002289465,0.0002593481,0.01537038,0.0002556005,0.9772991,0.00133492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04127125,0.9573739,0.00004329935,0.000007783867,0.0003354936,0.0003658596,0.0001613516,0.000003971539,0.0004371293],"genre_scores_gemma":[0.01111699,0.9879764,0.0004393435,0.00001984253,0.00004834449,0.00001447986,0.00009680444,0.00002104223,0.0002667279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9770267,"threshold_uncertainty_score":0.8578371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571133909459172,"score_gpt":0.30925588993904,"score_spread":0.2935445508444483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}