{"id":"W1971132352","doi":"10.1371/journal.pone.0058023","title":"Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Université de Sherbrooke; McGill University; Hospital for Sick Children; University of Ottawa; Jewish General Hospital; University of Toronto","funders":"National Eye Institute; National Institutes of Health; University of Florida; Canadian Institutes of Health Research; Macula Vision Research Foundation; Research to Prevent Blindness","keywords":"Mutant; Endothelin 1; Retinal degeneration; Biology; Internal medicine; Endocrinology; Molecular biology; Cell biology; Andrology; Medicine; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261207,0.0003985232,0.0003231283,0.0002564841,0.0001342476,0.000217065,0.0002538484,0.0003596368,0.00135437],"category_scores_gemma":[0.0001187858,0.0001873891,0.0003687112,0.00009701664,0.0001925305,0.0002570246,0.0002835469,0.0007687422,0.0002627113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223108,"about_ca_system_score_gemma":0.0001525842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004449304,"about_ca_topic_score_gemma":0.0008430929,"domain_scores_codex":[0.9998279,0.00002541075,0.00002297795,0.00005125687,0.00004519721,0.0000272189],"domain_scores_gemma":[0.9998434,0.0000195725,0.00004218448,0.00002144021,0.00001515301,0.0000582333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000407278,0.000008877323,0.00006356125,0.00001237582,0.000001891599,0.00003182416,0.000006393047,0.00001465179,0.9995109,0.00002039917,0.000008827858,0.0002796103],"study_design_scores_gemma":[0.00003009243,0.0003301411,0.009046583,0.000007962909,0.00001484313,0.0003862474,0.00002347784,0.0005990147,0.9882959,0.00003513045,0.001225511,0.000005212699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942026,0.001497482,0.002658801,0.00007724704,0.00004156128,0.00002046017,0.0004292557,0.00009993507,0.000972598],"genre_scores_gemma":[0.9866295,0.001071621,0.004620936,0.00009079171,0.00001583119,0.00005679054,0.0007326642,0.00006114797,0.006720632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135437,"threshold_uncertainty_score":0.004530787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933008934095015,"score_gpt":0.1955014491380028,"score_spread":0.1761713597970527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}