{"id":"W1971132352","doi":"10.1371/journal.pone.0058023","title":"Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Université de Sherbrooke; McGill University; Hospital for Sick Children; University of Ottawa; Jewish General Hospital; University of Toronto","funders":"National Eye Institute; National Institutes of Health; University of Florida; Canadian Institutes of Health Research; Macula Vision Research Foundation; Research to Prevent Blindness","keywords":"Mutant; Endothelin 1; Retinal degeneration; Biology; Internal medicine; Endocrinology; Molecular biology; Cell biology; Andrology; Medicine; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007972989,0.0001019479,0.0001277028,0.00007224073,0.00002076894,0.000010359,0.00007188093,0.0001124862,0.0002909866],"category_scores_gemma":[0.0001323737,0.00009863327,0.00002915723,0.0001366715,0.00003479725,0.000006631964,0.00002380668,0.0000579562,0.00004446908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001635622,"about_ca_system_score_gemma":0.00004147493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518472,"about_ca_topic_score_gemma":0.000058995,"domain_scores_codex":[0.9992503,0.00004472439,0.0002326284,0.0001858334,0.0001456889,0.0001408457],"domain_scores_gemma":[0.9996496,0.000005387983,0.00008296255,0.0001115481,0.0001110963,0.00003935627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000648912,0.0003850184,0.009804705,0.00003245349,0.00003426358,1.358803e-7,0.00007068953,0.000002925969,0.9891665,0.000001428991,0.00008513901,0.0003518575],"study_design_scores_gemma":[0.0005193928,0.0001783921,0.004338577,0.00003389239,0.000006688583,2.68911e-7,0.00005902188,0.000352087,0.9941379,0.00001808615,0.0002355827,0.000120099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986323,0.00009330846,0.00006420497,0.00006328094,0.00003810598,0.000671277,0.000007246198,0.00001204291,0.0004181948],"genre_scores_gemma":[0.9979315,0.0001498499,0.001088673,0.00005510798,0.00004866232,0.0002477922,0.0001784409,0.00001586081,0.0002840918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005466128,"threshold_uncertainty_score":0.4022148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933008934095015,"score_gpt":0.1955014491380028,"score_spread":0.1761713597970527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}