{"id":"W1971133648","doi":"10.1002/1438-826x(200010)1:3/4<134::aid-gnfd134>3.0.co;2-w","title":"Skeletal myopathy in mice over-expressing the human myotonic dystrophy protein kinase (DMPK) gene","year":2000,"lang":"en","type":"article","venue":"Gene Function & Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Ottawa; University of British Columbia; Children's Hospital of Eastern Ontario","funders":"","keywords":"Myotonic dystrophy; Myogenesis; Skeletal muscle; Biology; Myopathy; C2C12; Genetically modified mouse; Muscular dystrophy; Trinucleotide repeat expansion; Myotonia; Myocyte; Transgene; Muscle atrophy; Protein kinase A; Endocrinology; Internal medicine; Gene; Kinase; Cell biology; Genetics; Medicine; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005996816,0.001631619,0.0005205384,0.00173587,0.0009560475,0.0006597221,0.0005843861,0.001874379,0.005991525],"category_scores_gemma":[0.0002336993,0.001003991,0.0005879034,0.0005563889,0.001096081,0.0006711675,0.000695954,0.001844022,0.002293503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772095,"about_ca_system_score_gemma":0.0004921549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206312,"about_ca_topic_score_gemma":0.002444395,"domain_scores_codex":[0.9994648,0.00008873286,0.00006978014,0.0001829751,0.0001037034,0.0000899993],"domain_scores_gemma":[0.9996833,0.00006151426,0.0001089653,0.00002485424,0.00001805226,0.0001034814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004782553,0.0003167117,0.0003663196,0.00009728198,0.00002956589,0.0005433524,0.0001170909,0.0001286581,0.99447,0.0008939949,0.0003004265,0.002258391],"study_design_scores_gemma":[0.001285204,0.003833191,0.01819978,0.0002487199,0.0002686343,0.008002547,0.0002519212,0.00328437,0.9380862,0.00118268,0.02529354,0.00006325436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711761,0.002860358,0.008679663,0.0009971528,0.0002066419,0.0005013563,0.006090614,0.00138162,0.0081066],"genre_scores_gemma":[0.9310085,0.004709299,0.01775959,0.0006306451,0.00009694267,0.00110209,0.007116944,0.000472367,0.03710363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005991525,"threshold_uncertainty_score":0.02004361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675433955465347,"score_gpt":0.2430313641625135,"score_spread":0.2262770246078601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}