{"id":"W1971167085","doi":"10.1006/mthe.2002.0521","title":"The Nonapoptotic Pathway Mediating Thymidine Kinase/Ganciclovir Toxicity Is Reduced by Signal from Adenovirus Type 5 Early Region 4","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Thymidine kinase; Ganciclovir; Suicide gene; Apoptosis; Biology; Genetic enhancement; Programmed cell death; TUNEL assay; Gene delivery; Cytotoxicity; Adenoviridae; In vivo; Molecular biology; Viral vector; Toxicity; Transfection; Cell biology; In vitro; Gene; Virology; Chemistry; Human cytomegalovirus; Virus; Recombinant DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087224,0.000448605,0.00030983,0.0002693073,0.0001556681,0.000371885,0.0001938335,0.0002203324,0.001064785],"category_scores_gemma":[0.0002118759,0.0001137131,0.0002302423,0.0001465574,0.0002179813,0.0002346888,0.0002162175,0.0003698,0.0003148549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012722,"about_ca_system_score_gemma":0.0002677934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002572082,"about_ca_topic_score_gemma":0.0003098276,"domain_scores_codex":[0.9997301,0.00006330221,0.00002490452,0.00003029977,0.00009717986,0.00005428076],"domain_scores_gemma":[0.9998419,0.00004381983,0.00004801614,0.00001859138,0.0000241011,0.00002353934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007696082,0.00001971532,0.0001743032,0.00003097136,0.000003753034,0.00003478576,0.000006601104,0.00003052456,0.9981846,0.0000792253,0.00001308157,0.001345358],"study_design_scores_gemma":[0.00000859802,0.0001669778,0.001790485,0.000003411951,0.000008326369,0.0002165261,0.000009097641,0.0003281842,0.9967875,0.00003988855,0.0006396786,0.000001392995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940237,0.002329821,0.002477796,0.00004006669,0.00001584347,0.00001704197,0.00009013794,0.00005188914,0.000953638],"genre_scores_gemma":[0.9958253,0.001284229,0.001430535,0.0000172811,0.000005483749,0.00001481126,0.0002547334,0.00001068315,0.001157067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064785,"threshold_uncertainty_score":0.003562033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300260089879892,"score_gpt":0.2589534718558668,"score_spread":0.2359508709570678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}