{"id":"W1971167085","doi":"10.1006/mthe.2002.0521","title":"The Nonapoptotic Pathway Mediating Thymidine Kinase/Ganciclovir Toxicity Is Reduced by Signal from Adenovirus Type 5 Early Region 4","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Thymidine kinase; Ganciclovir; Suicide gene; Apoptosis; Biology; Genetic enhancement; Programmed cell death; TUNEL assay; Gene delivery; Cytotoxicity; Adenoviridae; In vivo; Molecular biology; Viral vector; Toxicity; Transfection; Cell biology; In vitro; Gene; Virology; Chemistry; Human cytomegalovirus; Virus; Recombinant DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003243057,0.0003633911,0.0002414031,0.00004766167,0.0003667102,0.0001285789,0.0007172237,0.0002751886,0.0001917837],"category_scores_gemma":[0.00007520042,0.0002910947,0.000193348,0.0003057241,0.0001855946,0.000009482636,0.0001089606,0.0003203665,0.000130538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004901878,"about_ca_system_score_gemma":0.00007587169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007394065,"about_ca_topic_score_gemma":0.00002136078,"domain_scores_codex":[0.9973515,0.000394322,0.0003451541,0.0006993732,0.0005658349,0.0006437958],"domain_scores_gemma":[0.9984594,0.00006385142,0.0001527756,0.0009581299,0.0001724589,0.0001933678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001115792,0.0001224973,0.0001395845,0.000002345154,0.0001760535,0.00002811663,0.0001648339,0.00001853699,0.9530177,0.000006038869,0.003892366,0.04131616],"study_design_scores_gemma":[0.001120399,0.002571282,0.0001246665,0.00001000337,0.00000883846,0.000005331799,0.00002658547,0.0002720372,0.9749087,0.0001692196,0.02042955,0.0003533894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736047,0.02369255,0.0004623897,0.001290648,0.0001598559,0.0004290198,0.0000500751,0.00004127187,0.000269496],"genre_scores_gemma":[0.9926137,0.003580587,0.00009685825,0.002348408,0.0003469115,0.00005091801,0.0001192061,0.0001028785,0.0007405686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04096277,"threshold_uncertainty_score":0.9999541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300260089879892,"score_gpt":0.2589534718558668,"score_spread":0.2359508709570678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}