{"id":"W1971170517","doi":"10.1046/j.0022-202x.2001.00012.x","title":"The Role of Phosphoinositide 3-Kinase in the Sorting and Transport of Newly Synthesized Tyrosinase-Related Protein-1 (TRP-1)","year":2001,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology Symposium Proceedings","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Wortmannin; Endosome; Cell biology; Melanosome; Biology; Transmembrane protein; Kinase; Protein kinase A; Tyrosinase; Golgi apparatus; Transport protein; Compartment (ship); Endocytic cycle; Cellular compartment; Biochemistry; Chemistry; Intracellular; Endocytosis; Phosphatidylinositol; Receptor; Endoplasmic reticulum; Melanin; Cell; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002645186,0.000312682,0.0001714327,0.0002482791,0.0006127195,0.0009349118,0.0003465092,0.0006906409,0.0009460778],"category_scores_gemma":[0.0002399619,0.0002306661,0.0002465608,0.0001229865,0.0003439675,0.001315066,0.0003270395,0.00071344,0.0005764241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075333,"about_ca_system_score_gemma":0.0003938364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241835,"about_ca_topic_score_gemma":0.001110887,"domain_scores_codex":[0.9999275,0.00001163021,0.000004901467,0.00001580558,0.00001097771,0.00002916578],"domain_scores_gemma":[0.9999217,0.00001807783,0.00001468036,0.000006629439,0.00001326005,0.0000257194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001727472,0.00005850577,0.0005438362,0.0001107719,0.00001112449,0.0004316995,0.00005674907,0.0004067943,0.9841402,0.003893743,0.0005092358,0.008109834],"study_design_scores_gemma":[0.0001517537,0.0003862761,0.0153364,0.00003581826,0.00004649917,0.001636163,0.0002982233,0.01064519,0.9534881,0.002813027,0.01512025,0.00004227616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654214,0.01998489,0.004668859,0.002182844,0.0002854102,0.00003298898,0.0002815819,0.0001046331,0.007037321],"genre_scores_gemma":[0.9858797,0.006167882,0.00282736,0.000188667,0.00007139866,0.00001780313,0.0002927225,0.00002351551,0.004530902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241835,"threshold_uncertainty_score":0.007802069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005691644395607071,"score_gpt":0.2167984518705103,"score_spread":0.2111068074749033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}