{"id":"W1971176613","doi":"10.1371/journal.pone.0021549","title":"Regulation of mTORC1 Signaling by pH","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"","keywords":"mTORC1; P70-S6 Kinase 1; Extracellular; Cell biology; TSC2; Biology; MAPK/ERK pathway; Protein kinase B; PI3K/AKT/mTOR pathway; Chemistry; Phosphorylation; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204729,0.0003751354,0.00017534,0.0002197197,0.0001865994,0.0003995468,0.0002026138,0.0002271163,0.00173833],"category_scores_gemma":[0.0001187292,0.0001073283,0.0002146832,0.0001438014,0.000247157,0.0001923052,0.0003124755,0.0003323234,0.0003263661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000446658,"about_ca_system_score_gemma":0.0002056157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003801122,"about_ca_topic_score_gemma":0.0004724604,"domain_scores_codex":[0.9998862,0.00001775556,0.000008813327,0.00002577395,0.00003201825,0.0000294678],"domain_scores_gemma":[0.9999242,0.00001363347,0.00002459541,0.000004986311,0.00001543965,0.00001716502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006043398,0.00003217287,0.0005202848,0.0002017635,0.00001642418,0.0001050616,0.00001199483,0.0002055127,0.994449,0.0002659033,0.0003352492,0.003252259],"study_design_scores_gemma":[0.00006761179,0.0003409575,0.02060124,0.00003422976,0.00004526359,0.0005349016,0.00004956142,0.002899868,0.9665126,0.0003425646,0.008555626,0.00001553953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696741,0.01727542,0.003400096,0.0005440651,0.0001091628,0.00005910563,0.001730687,0.0001842376,0.007023116],"genre_scores_gemma":[0.9911424,0.00484188,0.001639778,0.0001484689,0.00004677263,0.00004832773,0.0007049534,0.00002099584,0.001406333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173833,"threshold_uncertainty_score":0.005815327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04590520950502502,"score_gpt":0.2213971866342794,"score_spread":0.1754919771292544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}