{"id":"W1971215247","doi":"10.1002/jgm.248","title":"Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A","year":2002,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; McMaster University","funders":"Medical Research Council; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; Canadian Blood Services","keywords":"Genetic enhancement; C2C12; Immune system; Recombinant DNA; Gene delivery; Haemophilia A; Antibody; Molecular biology; Immunology; Antigen; Medicine; Chemistry; Haemophilia; Biology; Myocyte; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697879,0.0005024612,0.0002766087,0.0003083207,0.00009946855,0.0004341785,0.0002665417,0.0005381228,0.0007602311],"category_scores_gemma":[0.0001256429,0.000142786,0.0002786825,0.0001586881,0.0002864286,0.0002657505,0.0001333938,0.0005677757,0.000241079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002890228,"about_ca_system_score_gemma":0.0001901653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004216782,"about_ca_topic_score_gemma":0.0003724624,"domain_scores_codex":[0.999873,0.00001917083,0.00001234622,0.00003055437,0.0000363189,0.00002844218],"domain_scores_gemma":[0.9998702,0.00002504325,0.00005042475,0.00001642103,0.00001207998,0.00002589468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001453777,0.00005251097,0.0001037189,0.00003116107,0.000006468893,0.00002279553,0.000008921957,0.00005815993,0.9982924,0.00005467707,0.00002461499,0.00119919],"study_design_scores_gemma":[0.00004467713,0.001134729,0.00130616,0.000006799178,0.00004400734,0.0001662365,0.000007013115,0.0005254835,0.9955445,0.00002104174,0.001195327,0.00000406295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893254,0.002848662,0.006337353,0.0001246813,0.00003922158,0.00008147659,0.0002493183,0.0002117013,0.0007821546],"genre_scores_gemma":[0.9879689,0.001942226,0.007339668,0.00005055698,0.00002611491,0.00009819626,0.0003741351,0.00005059002,0.002149464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007602311,"threshold_uncertainty_score":0.002543211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08504130344408987,"score_gpt":0.3340068445871608,"score_spread":0.248965541143071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}