{"id":"W1971226986","doi":"10.1371/journal.ppat.1000007","title":"The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"Interferon; Biology; Gene knockdown; Virology; Reverse transcriptase; Viral replication; Group-specific antigen; Virus; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543006,0.0001355888,0.0001860194,0.00005443691,0.0003728509,0.000006491302,0.0001507699,0.0001332256,0.00008821472],"category_scores_gemma":[0.0006451402,0.00009636599,0.00008131341,0.0001606076,0.0003818512,0.00009548035,0.00005814063,0.0002286348,0.0002914353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004650497,"about_ca_system_score_gemma":0.00006561857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000708569,"about_ca_topic_score_gemma":0.000002214413,"domain_scores_codex":[0.9983231,0.000761508,0.0003527363,0.0002263233,0.0000528721,0.0002835024],"domain_scores_gemma":[0.9992267,0.0001917141,0.0001391499,0.0003431026,0.00008291437,0.00001635166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006474142,0.0002423623,0.0004532293,0.000005575469,0.00007706866,0.000001704458,0.001298813,8.338563e-7,0.9776075,0.00003644519,0.01217455,0.001627743],"study_design_scores_gemma":[0.0005233519,0.0006208397,0.002871383,0.00002735637,0.00002476869,0.0001374846,0.0005525093,0.00000288929,0.9739455,0.000006861461,0.02118246,0.0001045975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959135,0.001807803,0.00002110891,0.001246474,0.0005436128,0.000259911,0.0000315067,0.00006137538,0.0001147025],"genre_scores_gemma":[0.988508,0.0002465234,0.00001024623,0.00003477302,0.00002648507,0.00003672872,0.00002318373,0.0000168898,0.01109719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01098249,"threshold_uncertainty_score":0.3929691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384361221925871,"score_gpt":0.2264156673196204,"score_spread":0.2025720551003617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}