{"id":"W1971226986","doi":"10.1371/journal.ppat.1000007","title":"The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Fondation pour la Recherche Médicale","keywords":"Interferon; Biology; Gene knockdown; Virology; Reverse transcriptase; Viral replication; Group-specific antigen; Virus; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496542,0.0002351464,0.0002224,0.000135699,0.0001188189,0.0002805497,0.0001087404,0.000193293,0.001356224],"category_scores_gemma":[0.0001204601,0.0001000379,0.0002307205,0.0000802813,0.0001159664,0.0001063021,0.0001950637,0.0004175382,0.0006583335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016349,"about_ca_system_score_gemma":0.0001152459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001404339,"about_ca_topic_score_gemma":0.0002586675,"domain_scores_codex":[0.9998771,0.0000275484,0.00001246459,0.00002450322,0.00003153868,0.00002677549],"domain_scores_gemma":[0.9999146,0.00001786682,0.00002424006,0.0000145761,0.00001149797,0.00001730293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004386055,0.000007216993,0.0001077962,0.00002096296,0.000002493139,0.00002072128,0.000004750117,0.00001912398,0.9987802,0.00004159232,0.00003574169,0.0009156937],"study_design_scores_gemma":[0.000006625984,0.00009452942,0.002223244,0.00000476053,0.000007202452,0.0001430344,0.000009544183,0.0003713411,0.9942889,0.00002773965,0.002821144,0.000001791207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862078,0.005474865,0.004435068,0.0002086643,0.00005117788,0.00003732364,0.0004833653,0.0001363673,0.002965309],"genre_scores_gemma":[0.9907294,0.001445261,0.003408742,0.0001329853,0.00002322643,0.00004025609,0.0008472439,0.00003156394,0.003341252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356224,"threshold_uncertainty_score":0.004536986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02384361221925871,"score_gpt":0.2264156673196204,"score_spread":0.2025720551003617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}