{"id":"W1971227589","doi":"10.1006/excr.2000.5030","title":"The tkNeo Gene, but Not the pgkPuro Gene, Can Influence the Ability of the β-Globin LCR to Enhance and Confer Position-Independent Expression onto the β-Globin Gene","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Biology; Gene; Transfection; Globin; Gene expression; Molecular biology; Position effect; Plasmid; Transgene; Gene cluster; Regulation of gene expression; Selectable marker; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001190914,0.0002209121,0.0001394834,0.00001862057,0.001194317,0.0001657632,0.001453126,0.0001257067,0.0001205471],"category_scores_gemma":[0.00005540163,0.0000951046,0.0001249232,0.0001600973,0.0007598809,0.00001119696,0.0008118366,0.0003880474,0.0000296466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008092885,"about_ca_system_score_gemma":0.0001996526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629786,"about_ca_topic_score_gemma":0.0003711049,"domain_scores_codex":[0.9970581,0.000795365,0.0003271116,0.0005447391,0.0007576977,0.0005170178],"domain_scores_gemma":[0.9980528,0.0001730782,0.00007571017,0.001358541,0.0002273593,0.0001124612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003731548,0.00008805874,0.0002487233,0.000004465015,0.00002285578,0.000001707958,0.000984303,0.000129205,0.9950469,0.00001783107,0.002021224,0.001061643],"study_design_scores_gemma":[0.0001939342,0.0003304329,0.007416847,0.00001585685,0.000005843768,0.00001673182,0.001643707,0.00004058031,0.98421,0.00003312955,0.00596534,0.0001275738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920756,0.003203632,0.00002520098,0.002089419,0.00009837776,0.001012986,0.00006214935,0.00000483165,0.001427786],"genre_scores_gemma":[0.9949335,0.00070301,0.00003912038,0.001060204,0.0001428727,0.0002610727,0.00001218436,0.0000194456,0.002828526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01083681,"threshold_uncertainty_score":0.9185841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467981915014588,"score_gpt":0.3236740001948715,"score_spread":0.3089941810447256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}