{"id":"W1971227589","doi":"10.1006/excr.2000.5030","title":"The tkNeo Gene, but Not the pgkPuro Gene, Can Influence the Ability of the β-Globin LCR to Enhance and Confer Position-Independent Expression onto the β-Globin Gene","year":2000,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Ottawa Hospital; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Biology; Gene; Transfection; Globin; Gene expression; Molecular biology; Position effect; Plasmid; Transgene; Gene cluster; Regulation of gene expression; Selectable marker; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166781,0.0005008968,0.0002849751,0.0002844254,0.0001642097,0.0004994237,0.0003337175,0.0003044876,0.001564597],"category_scores_gemma":[0.000315643,0.0002415539,0.0002512658,0.0001630205,0.0005443526,0.000295533,0.0002907681,0.0008600935,0.0006437068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003375009,"about_ca_system_score_gemma":0.0002727419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008090359,"about_ca_topic_score_gemma":0.001477715,"domain_scores_codex":[0.9997702,0.00003185395,0.00002713641,0.00005602514,0.00005793724,0.00005681349],"domain_scores_gemma":[0.999579,0.0001894839,0.00007520131,0.0000625851,0.00001700569,0.00007665959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006712322,0.00001218664,0.00007691497,0.00001137104,0.000001606884,0.00003481338,0.000009488645,0.00002436195,0.9991743,0.0001301006,0.000009860929,0.0004478714],"study_design_scores_gemma":[0.00001003825,0.00004420705,0.001035822,0.00000300173,0.000007025765,0.0001314579,0.000009842173,0.0002627198,0.9974059,0.00003629032,0.001050398,0.000003327395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879625,0.000609876,0.00688744,0.0001249583,0.0000647633,0.00003242295,0.0003691931,0.0001563934,0.003792339],"genre_scores_gemma":[0.9881467,0.0004356046,0.004125022,0.00006723898,0.00001575368,0.00002252379,0.0009390789,0.0001973463,0.006050888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564597,"threshold_uncertainty_score":0.005234063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467981915014588,"score_gpt":0.3236740001948715,"score_spread":0.3089941810447256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}