{"id":"W1971249078","doi":"10.1371/journal.pone.0111242","title":"Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Xiangya Hospital, Central South University; Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Diabetic nephropathy; Endocrinology; Internal medicine; Medicine; Losartan; Creatinine; Diabetes mellitus; Renal function; Nephropathy; Albuminuria; Kidney disease; Angiotensin II","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002522363,0.000568299,0.0005656371,0.0005717406,0.0001688019,0.0003307557,0.0003714308,0.0006391436,0.001172905],"category_scores_gemma":[0.0001194563,0.0002156003,0.0005124144,0.0001865793,0.0002215881,0.0004883608,0.0001190793,0.001206579,0.0002005269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196273,"about_ca_system_score_gemma":0.0002711931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008337486,"about_ca_topic_score_gemma":0.001164545,"domain_scores_codex":[0.9998202,0.00002159942,0.00001941614,0.00003404455,0.00003484638,0.00006998691],"domain_scores_gemma":[0.9998041,0.00001368017,0.00005631642,0.0000144478,0.00002210786,0.00008940765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002650116,0.0005811839,0.0001818975,0.00007062439,0.00001197868,0.00005180628,0.00001757781,0.00005567881,0.9932982,0.0000746157,0.00006325599,0.002943021],"study_design_scores_gemma":[0.0003309879,0.009477727,0.008462133,0.00002758276,0.00008231228,0.0002827617,0.00004435483,0.0006138514,0.9782707,0.0001032018,0.002283932,0.00002044404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944566,0.002127879,0.001630026,0.0001801638,0.00006357229,0.00003477606,0.0003449916,0.0001517528,0.00101011],"genre_scores_gemma":[0.9899212,0.002450691,0.002692016,0.000197459,0.00004635889,0.00008508997,0.0005799248,0.00003288554,0.003994481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172905,"threshold_uncertainty_score":0.003923714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250549393819531,"score_gpt":0.2175517886430066,"score_spread":0.1950462947048113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}