{"id":"W1971249330","doi":"10.4161/isl.19982","title":"Elevation of transcription factor Islet-1 levels in vivo increases β-cell function but not β-cell mass","year":2012,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Islet; Downregulation and upregulation; Biology; Endocrinology; Transcription factor; Internal medicine; Glucose homeostasis; Secretion; In vivo; Cell; Genetically modified mouse; Microarray analysis techniques; Microarray; Cell biology; Ectopic expression; Transgene; Gene expression; Insulin; Gene; Insulin resistance; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002215591,0.0001674796,0.0003148927,0.0002277865,0.00003106348,0.000008217756,0.00004196041,0.0001477034,0.00181918],"category_scores_gemma":[0.0001134503,0.0001532714,0.000100719,0.0002175511,0.00003595051,0.0002749844,0.000007047369,0.0001391116,0.0001299674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009192897,"about_ca_system_score_gemma":0.00005262265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290065,"about_ca_topic_score_gemma":0.000002790195,"domain_scores_codex":[0.9987532,0.0000759507,0.0003802492,0.0001861948,0.0003108584,0.0002934987],"domain_scores_gemma":[0.9993106,0.0001201188,0.0001338774,0.0002149838,0.00008801123,0.0001324535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000319276,0.0005844866,0.03035868,0.0001960965,0.0000145569,0.000001665494,0.0001906257,0.000004327385,0.9667507,0.00007035094,0.0007855824,0.0007236241],"study_design_scores_gemma":[0.002808911,0.0003203269,0.1286085,0.00007595487,0.0001002917,0.000003126496,0.0001747078,0.0001551929,0.8639051,0.00003946505,0.003662974,0.0001454581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881941,0.0003229924,0.001764445,0.0001091361,0.0004869011,0.000315664,0.00006612701,0.00005884906,0.008681802],"genre_scores_gemma":[0.9955557,0.00003167818,0.0003515095,0.0005886964,0.0002417621,0.0000228223,0.00003430738,0.00002252877,0.003151003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1028456,"threshold_uncertainty_score":0.9990933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03216897208821146,"score_gpt":0.2484970385926202,"score_spread":0.2163280665044088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}