{"id":"W1971253387","doi":"10.1007/s10974-010-9213-x","title":"The role of tropomyosin isoforms and phosphorylation in force generation in thin-filament reconstituted bovine cardiac muscle fibres","year":2010,"lang":"en","type":"article","venue":"Journal of Muscle Research and Cell Motility","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Memorial University of Newfoundland","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Tropomyosin; Cooperativity; Actin; Chemistry; Phosphorylation; CrossBridge; Gene isoform; Biophysics; Protein filament; Gelsolin; Myosin; Analytical Chemistry (journal); Biochemistry; Chromatography; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003532035,0.00007950422,0.000292258,0.0001536742,0.0001423451,0.00003135402,0.00005581102,0.0000722839,0.00000760015],"category_scores_gemma":[0.00033552,0.00005177877,0.00006734866,0.0002003622,0.0002868061,0.0001485564,0.00004668483,0.0005858697,2.587107e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006279619,"about_ca_system_score_gemma":0.0001378768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002978335,"about_ca_topic_score_gemma":0.0003828737,"domain_scores_codex":[0.998683,0.000139468,0.00042487,0.0001345255,0.0003957773,0.0002223576],"domain_scores_gemma":[0.9990812,0.0002224329,0.0001147375,0.0001594853,0.0003170774,0.0001050874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009537022,0.0003453241,0.1549141,0.0001279966,0.00004037067,0.00002071044,0.001839318,0.00001126025,0.6783139,0.0001827879,0.0003228243,0.1629276],"study_design_scores_gemma":[0.001387845,0.000672121,0.9199132,0.0000700553,0.00001652099,0.00001863636,0.002626225,0.0006218167,0.06867752,0.0009491023,0.004996968,0.000049978],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990326,0.007806172,0.00001209962,0.000649034,0.00008580767,0.0002908239,0.000003728699,0.000001959052,0.0008243074],"genre_scores_gemma":[0.9953765,0.004259911,0.0001565446,0.000006193032,0.0001262142,0.000005671176,0.000002110934,0.000004713395,0.00006219224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7649991,"threshold_uncertainty_score":0.2545345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02328396092686758,"score_gpt":0.2941881372895435,"score_spread":0.2709041763626759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}