{"id":"W1971281104","doi":"10.1371/journal.pone.0032281","title":"Genomic Regions Associated with Multiple Sclerosis Are Active in B Cells","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; GW Pharmaceuticals; Vertex Pharmaceuticals; Ironwood Pharmaceuticals, Incorporated; Universitetet i Oslo; Five Prime Therapeutics; Wellcome Trust; Merz Pharmaceuticals; Teva Pharmaceutical Industries; Fondazione Italiana Sclerosi Multipla; Medical Research Council; Biogen; GlaxoSmithKline; Pfizer","keywords":"Enhancer; Biology; Single-nucleotide polymorphism; Multiple sclerosis; Chromatin; Gene; Genetics; Molecular biology; Transcription factor; Immunology; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002919601,0.0002114081,0.0003654161,0.00100085,0.0003323602,0.0005588473,0.0001490589,0.0003677098,0.005243946],"category_scores_gemma":[0.0008873677,0.0002411369,0.0004978034,0.002017911,0.0002160359,0.0002208242,0.0004990639,0.0003139212,0.001090514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244281,"about_ca_system_score_gemma":0.0002002442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186832,"about_ca_topic_score_gemma":0.00264986,"domain_scores_codex":[0.9994496,0.00008540699,0.00004083544,0.0002114745,0.0001430219,0.00006977195],"domain_scores_gemma":[0.9988754,0.0004621929,0.0003915279,0.0001080572,0.00005872202,0.0001040726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002210592,0.00008288097,0.2323925,0.000807478,0.0007125982,0.001113283,0.0006008855,0.0009198702,0.7214125,0.0007126553,0.001939827,0.03709485],"study_design_scores_gemma":[0.00004170139,0.0001221709,0.9735077,0.00004739522,0.0002335466,0.001700507,0.0001651683,0.0004940278,0.01669488,0.0006772921,0.006298251,0.00001741283],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830308,0.002054289,0.002956798,0.0001212703,0.00001370754,0.00001612876,0.009124101,0.000318689,0.002364279],"genre_scores_gemma":[0.9817373,0.0006623601,0.006127974,0.0001328938,0.00002296766,0.00002794603,0.01031344,0.00007745188,0.0008977239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005243946,"threshold_uncertainty_score":0.01754278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1848505360931593,"score_gpt":0.2764845820376343,"score_spread":0.09163404594447497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}