{"id":"W1971289691","doi":"10.1055/s-2007-993754","title":"Reversal of P-Glycoprotein-Mediated Drug Efflux by Eudesmin from <i>Haplophyllum perforatum</i> and Cytotoxicity Pattern versus Diphyllin, Podophyllotoxin and Etoposide","year":2007,"lang":"en","type":"article","venue":"Planta Medica","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"Novartis Pharma; Institut National de la Santé et de la Recherche Médicale","keywords":"Podophyllotoxin; Etoposide; Lignan; Cytotoxicity; Pharmacology; P-glycoprotein; Efflux; Multiple drug resistance; In vivo; Doxorubicin; IC50; Cancer cell; Chemistry; In vitro; Biochemistry; Biology; Medicine; Cancer; Chemotherapy; Stereochemistry; Internal medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005226198,0.000279785,0.0003694832,0.00004893264,0.00009244808,0.00002047249,0.0002009815,0.0002916522,0.00002818928],"category_scores_gemma":[0.0001675005,0.0002454048,0.00005973189,0.00007056328,0.0003043621,0.00001094299,0.0001574496,0.00022396,0.000004377769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001465926,"about_ca_system_score_gemma":0.00006063793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006909652,"about_ca_topic_score_gemma":0.000418871,"domain_scores_codex":[0.9983312,0.0001022766,0.0003466377,0.0005361298,0.0003079341,0.0003757525],"domain_scores_gemma":[0.9989194,0.0002998957,0.0001936017,0.0002806204,0.00003703349,0.000269496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007787075,0.0001145867,0.01659591,0.00004694366,0.0001222274,0.00002675752,0.00009939141,8.330758e-8,0.9765021,0.000001511465,0.003144042,0.002567761],"study_design_scores_gemma":[0.001703508,0.0003401824,0.01826365,0.00008223757,0.00005927903,0.00002351747,0.0001349569,0.00004023975,0.9742447,0.000005316492,0.00478856,0.0003138319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962901,0.001058453,0.0003533222,0.0001688861,0.0001702948,0.0002542769,0.001456938,0.00001756451,0.0002301003],"genre_scores_gemma":[0.9974973,0.001037052,0.0002526824,0.0002246244,0.00021315,0.00000925126,0.0006785691,0.0000250084,0.0000623254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257348,"threshold_uncertainty_score":0.9999998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00564568416232078,"score_gpt":0.2071854396050956,"score_spread":0.2015397554427749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}