{"id":"W1971289691","doi":"10.1055/s-2007-993754","title":"Reversal of P-Glycoprotein-Mediated Drug Efflux by Eudesmin from <i>Haplophyllum perforatum</i> and Cytotoxicity Pattern versus Diphyllin, Podophyllotoxin and Etoposide","year":2007,"lang":"en","type":"article","venue":"Planta Medica","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"Novartis Pharma; Institut National de la Santé et de la Recherche Médicale","keywords":"Podophyllotoxin; Etoposide; Lignan; Cytotoxicity; Pharmacology; P-glycoprotein; Efflux; Multiple drug resistance; In vivo; Doxorubicin; IC50; Cancer cell; Chemistry; In vitro; Biochemistry; Biology; Medicine; Cancer; Chemotherapy; Stereochemistry; Internal medicine; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007438409,0.0002069465,0.0002163047,0.0001145004,0.0000598724,0.0001650159,0.00009990144,0.0001437998,0.0004906562],"category_scores_gemma":[0.00008633195,0.00006943763,0.0001104362,0.0001063495,0.000125324,0.0001725821,0.00008856451,0.00024496,0.0001203215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279842,"about_ca_system_score_gemma":0.0000880536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002272387,"about_ca_topic_score_gemma":0.0003718696,"domain_scores_codex":[0.9999557,0.00001159247,0.000005145535,0.000007985424,0.000006376913,0.00001336279],"domain_scores_gemma":[0.9999477,0.00001339438,0.00001700513,0.000005813624,0.000006037371,0.00001004207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001413997,0.00001353234,0.0002056084,0.00002080905,0.000003584052,0.00002830522,0.000006038962,0.00004505312,0.9983841,0.00002455272,0.000006387673,0.001120638],"study_design_scores_gemma":[0.00001525957,0.0006864623,0.004507987,0.000003161823,0.00001083533,0.0001620991,0.00001735987,0.0001747562,0.9935987,0.00001542982,0.0008058224,0.00000214677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986513,0.0005945935,0.00025142,0.0000190721,0.000004006729,0.000006436622,0.00006841539,0.000007926495,0.000396817],"genre_scores_gemma":[0.9981802,0.0003770981,0.0006250703,0.00002034021,0.000003046802,0.000006421013,0.0002398669,0.000005797606,0.0005421137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004906562,"threshold_uncertainty_score":0.001641452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00564568416232078,"score_gpt":0.2071854396050956,"score_spread":0.2015397554427749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}