{"id":"W1971314625","doi":"10.1002/jcb.20511","title":"Roles of Ca2+ and the Ca2+‐sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)‐2 and its BH4 (tetrahydrobiopterin)‐dependent activation in cytokine‐stimulated adult human astrocytes","year":2005,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; Toronto Public Health","funders":"","keywords":"Proinflammatory cytokine; Nitric oxide synthase; Tetrahydrobiopterin; MAPK/ERK pathway; Chemistry; Nitric oxide; p38 mitogen-activated protein kinases; Receptor; Cell biology; Astrocyte; Molecular biology; Biochemistry; Biology; Signal transduction; Endocrinology; Enzyme; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712661,0.0003083798,0.0002613941,0.0001226925,0.0001657115,0.0004192537,0.0002534667,0.0004442632,0.0006737586],"category_scores_gemma":[0.0002778266,0.0002353835,0.0002946777,0.00008340055,0.0003948032,0.0005594536,0.0002268705,0.0003581436,0.0002602522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927132,"about_ca_system_score_gemma":0.0003330352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005762401,"about_ca_topic_score_gemma":0.0009034128,"domain_scores_codex":[0.9998036,0.00003946988,0.00002655063,0.00003139918,0.00004300089,0.00005589172],"domain_scores_gemma":[0.9997962,0.00003829641,0.00007151301,0.00002029745,0.00002565021,0.0000480319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001316753,0.00004285784,0.0006403042,0.00006663761,0.000009189533,0.0002360749,0.00004107476,0.00008054067,0.9953579,0.0002904772,0.00003398978,0.00188418],"study_design_scores_gemma":[0.0001978943,0.000968175,0.04065974,0.00002218308,0.00006814596,0.001756883,0.0002175026,0.003157523,0.9489542,0.0006116834,0.003361568,0.00002462934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879249,0.006749731,0.002890047,0.0003087325,0.00003817076,0.00002415377,0.000152897,0.00004146626,0.001869816],"genre_scores_gemma":[0.9944873,0.001278457,0.002151841,0.00008359931,0.00002700844,0.00004611969,0.0001311871,0.00001144038,0.001782878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006737586,"threshold_uncertainty_score":0.002254009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008386586316207853,"score_gpt":0.2306372987954452,"score_spread":0.2222507124792373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}