{"id":"W1971314625","doi":"10.1002/jcb.20511","title":"Roles of Ca2+ and the Ca2+‐sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)‐2 and its BH4 (tetrahydrobiopterin)‐dependent activation in cytokine‐stimulated adult human astrocytes","year":2005,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; Toronto Public Health","funders":"","keywords":"Proinflammatory cytokine; Nitric oxide synthase; Tetrahydrobiopterin; MAPK/ERK pathway; Chemistry; Nitric oxide; p38 mitogen-activated protein kinases; Receptor; Cell biology; Astrocyte; Molecular biology; Biochemistry; Biology; Signal transduction; Endocrinology; Enzyme; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001133945,0.0003088701,0.0006951892,0.0003336045,0.00008104117,0.00003032039,0.0002080651,0.0002831629,0.00001670847],"category_scores_gemma":[0.0006256712,0.0002030886,0.0001510626,0.0003903906,0.0001530248,0.0001674457,0.00006922786,0.0007610003,0.00000125511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100863,"about_ca_system_score_gemma":0.0001020137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006671809,"about_ca_topic_score_gemma":0.000002506749,"domain_scores_codex":[0.9975498,0.0002361462,0.001050803,0.000284657,0.0005729333,0.0003056486],"domain_scores_gemma":[0.9981161,0.0004593065,0.0007008603,0.0003282606,0.0002679724,0.0001274946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098207,0.0002683196,0.0003994649,0.0003999681,0.00006354565,0.00005008387,0.001105493,0.004993138,0.9907448,0.000001102784,0.000102171,0.000773686],"study_design_scores_gemma":[0.006213139,0.000174396,0.0002535965,0.001606284,0.0001389204,0.0002549319,0.001933555,0.009028811,0.9802009,0.00001212249,0.00001493237,0.0001684091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980854,0.001077608,0.00007243846,0.0002842412,0.00001271074,0.000375958,0.00004881792,0.00000668126,0.00003615227],"genre_scores_gemma":[0.9990426,0.0002922458,0.0002672459,0.00008175361,0.0002168587,0.000004358928,0.00005928868,0.0000263708,0.000009302431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01054392,"threshold_uncertainty_score":0.8281711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008386586316207853,"score_gpt":0.2306372987954452,"score_spread":0.2222507124792373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}